Ethnic and sex differences in the total and differential white cell count and platelet count
Ethnic and sex differences in the total and differential white cell count and platelet count
复制标题
DOI：
10.1136/jcp.49.8.664
复制
发表时间：
1996-08-01
影响因子：
3.4
通讯作者：
Bain, BJ
中科院分区：
文献类型：
--
作者：
Bain, BJ
目的/背景-以前的研究表明，非洲血统的健康受试者的总白色细胞计数、中性粒细胞计数和血小板计数低于高加索受试者，并且至少在高加索人中，女性的中性粒细胞和血小板计数高于男性。本研究的主要目的是确认和量化种族差异，确认高加索人的性别差异，并确定非高加索人中是否存在类似的性别差异，第二个目的是建立不同种族和性别群体的白色细胞和血小板计数的参考范围。研究人群由417名健康志愿者组成（201名女性和216名男性），其中200名为高加索人，102名为非洲加勒比人，115名为非洲人，使用H. 2自动分类计数器测量全血细胞计数，包括分类白色细胞计数，比较了三个不同种族群体之间以及男性和女性之间的白色细胞和血小板计数。参考范围确定为每个种族和性别group.Results-Africans和Afrocaribbeans有较低的总白色细胞，中性粒细胞和血小板计数比高加索人和计数低于非洲人比Afrocaribbeans，妇女有较高的中性粒细胞和血小板计数比男性在所有ethnic group. Conclusions性别和种族血统应考虑评估白色细胞和血小板计数。
Aim/Background-Previous studies have suggested that healthy subjects of African ancestry have lower total white cell counts, neutrophil counts and platelet counts than Caucasian subjects and that, at least among Caucasians, women have higher neutrophil and platelet counts than men, The primary aim of this study was to confirm and quantify the ethnic differences, confirm the sex difference in Caucasians and determine whether there was a similar sex difference in non-Caucasians, A secondary aim was to establish reference ranges for white cell and platelet counts for the different ethnic and sex groups.Methods-The study population comprised 417 healthy volunteers (201 women and 216 men), of whom 200 were Caucasian, 102 were Afrocaribbean and 115 were African, Full blood counts, including a differential white cell count, were measured using a H.2 automated differential counter, White cell and platelet counts were compared between the three different ethnic groups and between men and women. Reference ranges were determined for each ethnic and sex group.Results-Africans and Afrocaribbeans had lower total white cell, neutrophil and platelet counts than Caucasians and counts were lower in Africans than in Afrocaribbeans, Women had higher neutrophil and platelet counts than men in all ethnic groups.Conclusions-Sex and ethnic origin should be taken into consideration where assessing white cell and platelet counts.