Creatine kinase activity inhibitor in sera from patients with muscle disease.
Creatine kinase activity inhibitor in sera from patients with muscle disease.
复制标题
肌肉疾病患者血清中的肌酸激酶活性抑制剂。
作者：
L. Kagen;S. Aram
肌肉疾病患者的血清中含有肌酸激酶（CK）抑制剂，这可能导致对CK活性的低估。该抑制剂可透析，但与先前描述的低分子量CK抑制剂无关。在一小群肌炎患者中，血清中抑制剂的含量与疾病的严重程度相关。我们的研究结果表明，CK抑制剂可能从受伤的肌肉释放到血清中。
Sera from patients with muscle disease contain an inhibitor of creatine kinase (CK) which may lead to underestimation of CK activity. The inhibitor was dialyzable, but was not related to previously described low molecular weight inhibitors of CK. In a small group of patients with myositis, the amount of inhibitor present in serum was correlated with the severity of the illness. Our findings suggest that the CK inhibitor may be released into serum from injured muscle.