Vitamin D-related gene polymorphisms do not influence the outcome and serum vitamin D level in pegylated interferon/ribavirin therapy combined with protease inhibitor for patients with genotype 1b chronic hepatitis C.
Vitamin D-related gene polymorphisms do not influence the outcome and serum vitamin D level in pegylated interferon/ribavirin therapy combined with protease inhibitor for patients with genotype 1b chronic hepatitis C.
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维生素D相关基因多态性不影响聚乙二醇干扰素/利巴韦林联合蛋白酶抑制剂治疗基因1b型慢性丙型肝炎患者的结局和血清维生素D水平。
DOI：
10.1002/jmv.24244
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发表时间：
2015
期刊：
影响因子：
12.7
通讯作者：
Iwakiri K.
中科院分区：
文献类型：
--
作者：
Arai T;Atsukawa M;Tsubota A;Kondo C;Shimada N;Abe H;Itokawa N;Nakagawa A;Okubo T;Aizawa Y;Iwakiri K.
尽管有报道称，几种维生素D相关基因多态性会影响聚乙二醇干扰素/利巴韦林（PR）治疗慢性丙型肝炎患者的结局，但尚无关于维生素D相关基因多态性对PR治疗联合蛋白酶抑制剂（PI）的影响的报道。在177例基因型1b感染的慢性丙型肝炎患者中确定了维生素D相关基因多态性，这些患者接受了12周的telaprevir PR治疗，第一代PI，随后接受了12周的PR治疗。持续病毒学应答（SVR）率为83.1%（147/177例）。维生素D相关基因多态性的频率为：GC的83种非TT和94种TT基因型，DHCR 7的97种非AA和80种AA基因型，CYP 2 R1的151种非AA和26种AA基因型，CYP 27 B1的162种非GG和15种GG基因型，VDR基因的105种非GG和72种GG基因型。多因素分析显示IL 28 BTT基因型（P= 2.05×10−6）和血清25（OH）D3水平（P= 0.024）是影响SVR的独立因素。血清25（OH）D3水平<25 ng/ml的IL 28 BTT基因型患者的SVR率显著低于其他患者。维生素D相关基因多态性均不影响治疗结果和血清25（OH）D3水平。总之，IL 28 B多态性和血清25（OH）D3水平对1b基因型慢性丙型肝炎患者PR合并PI的SVR有显著且独立的贡献。然而，维生素D相关基因多态性对治疗结果和血清25（OH）D3水平无影响。© 2015 Wiley Periodicals，Inc.
Although several vitamin D‐related gene polymorphisms were reported to affect the outcome of pegylated interferon/ribavirin (PR) therapy in chronic hepatitis C patients, there are no reports on the impact of the vitamin D‐related gene polymorphisms in PR therapy combined with protease inhibitor (PI). Vitamin D‐related gene polymorphisms were determined in 177 genotype 1b‐infected chronic hepatitis C patients who received 12 weeks of PR therapy with telaprevir, a first‐generation PI, followed by 12 weeks of PR therapy. The sustained virologic response (SVR) rate was 83.1% (147 of 177 patients). The frequencies of vitamin D‐related gene polymorphisms were: 83 non‐TT and 94 TT genotypes for GC, 97 non‐AA and 80 AA genotypes forDHCR7, 151 non‐AA and 26 AA genotypes forCYP2R1, 162 non‐GG and 15 GG genotypes forCYP27B1, and 105 non‐GG and 72 GG genotypes forVDR gene. Multivariate analysis extractedIL28BTT genotype (P= 2.05×10−6) and serum 25(OH) D3level (P= 0.024) as independent factors contributing to the achieving of SVR. The SVR rate inIL28BTT genotype patients with serum 25(OH) D3level of <25 ng/ml was significantly low compared to other patients. None of the vitamin D‐related gene polymorphisms affected the treatment outcome and serum 25(OH) D3level. In conclusions, theIL28Bpolymorphism and serum 25(OH) D3level contributed significantly and independently to SVR in PR combined with PI for genotype 1b‐infected chronic hepatitis C patients. However, none of vitamin D‐related gene polymorphisms had an impact on the treatment outcome and serum 25(OH) D3level.J. Med. Virol. 87:1904–1912, 2015.© 2015 Wiley Periodicals, Inc.