Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer.
Luminal membrane expression of mesothelin is a prominent poor prognostic factor for gastric cancer.
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DOI：
10.1038/bjc.2012.235
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发表时间：
2012-06-26
影响因子：
8.8
通讯作者：
Todo S
中科院分区：
文献类型：
--
作者：
Einama T;Homma S;Kamachi H;Kawamata F;Takahashi K;Takahashi N;Taniguchi M;Kamiyama T;Furukawa H;Matsuno Y;Tanaka S;Nishihara H;Taketomi A;Todo S
间皮素在各种类型的恶性肿瘤中表达，我们最近报道了间皮素的表达与胰腺导管腺癌患者的不良预后有关。在这项研究中，我们研究了间皮素在胃癌中的表达的临床病理意义，特别是在其与染色模式的关联方面。本文对110例胃癌患者的组织标本进行了免疫组化检查。分析肿瘤细胞中间皮素表达的染色比例和强度，并将间皮素的定位分类为管腔膜和/或细胞质表达。间皮素阳性49例，间皮素阳性率与淋巴结转移有关。此外，在16例病例中鉴定了间皮素的管腔膜染色，并且管腔膜表达的发生率也与pT因子、pStage、淋巴渗透、血管渗透、复发和不良患者结局相关。多变量分析显示，间皮素的管腔膜表达是患者总体生存的独立预测因子。我们描述了间皮素的管腔膜表达是胃癌的一个可靠的预后因素，表明膜定位的间皮素在胃癌细胞的侵袭行为中的功能意义。
Mesothelin is expressed in various types of malignant tumour, and we recently reported that expression of mesothelin was related to an unfavourable patient outcome in pancreatic ductal adenocarcinoma. In this study, we examined the clinicopathological significance of the mesothelin expression in gastric cancer, especially in terms of its association with the staining pattern. Tissue specimens from 110 gastric cancer patients were immunohistochemically examined. The staining proportion and intensity of mesothelin expression in tumour cells were analysed, and the localisation of mesothelin was classified into luminal membrane and/or cytoplasmic expression. Mesothelin was positive in 49 cases, and the incidence of mesothelin expression was correlated with lymph-node metastasis. Furthermore, luminal membrane staining of mesothelin was identified in 16 cases, and the incidence of luminal membrane expression was also correlated with pT factor, pStage, lymphatic permeation, blood vessel permeation, recurrence, and poor patient outcome. Multivariate analysis showed that luminal membrane expression of mesothelin was an independent predictor of overall patient survival. We described that the luminal membrane expression of mesothelin was a reliable prognostic factor in gastric cancer, suggesting the functional significance of membrane-localised mesothelin in the aggressive behaviour of gastric cancer cells.
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影响因子：
3.3
作者：
Swierczynski, SL;Maitra, A;Argani, P
通讯作者：
Argani, P
影响因子：
5.7
作者：
Li, Min;Bharadwaj, Uddalak;Yao, Qizhi
通讯作者：
Yao, Qizhi
影响因子：
5.2
作者：
Bharadwaj, Uddalak;Li, Min;Yao, Qizhi
通讯作者：
Yao, Qizhi
影响因子：
4.1
作者：
Chang, Ming-Cheng;Chen, Chi-An;Cheng, Wen-Fang
通讯作者：
Cheng, Wen-Fang
影响因子：
6.4
作者：
CHANG, K;PASTAN, I;WILLINGHAM, MC
通讯作者：
WILLINGHAM, MC