Homocysteine and its disulfide derivatives -: A suggested consensus terminology
Homocysteine and its disulfide derivatives -: A suggested consensus terminology
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DOI：
10.1161/01.atv.20.7.1704
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发表时间：
2000-07-01
影响因子：
8.7
通讯作者：
Rosenberg, IH
中科院分区：
文献类型：
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作者：
Mudd, SH;Finkelstein, JD;Rosenberg, IH
近年来，作为心血管疾病的独立危险因素，高半胱氨酸和密切相关的代谢物的血浆浓度升高引起了极大的关注（例如，在参考文献1至3中进行了综述）。同型半胱氨酸本身是一种含巯基的氨基酸，但在正常人血浆和其他组织中，可能存在各种相关的二硫化物衍生物。不同的作者使用不同的术语来描述这些化合物及其影响。为了促进含义的清晰度和最小化不确定性，甚至可能混淆，重要的是，讨论这些化合物的每篇文章明确定义所使用的术语和/或缩写，或引用提供此类定义的先前出版物。最理想的情况是，该领域将开发和采用更统一的共识术语。本文简要介绍了相关化合物的结构，并列出了一些术语和缩写，希望能为这一共识提供基础。65年前，Du Vigneaud及其同事首次使用了“同型半胱氨酸”一词，当时他们发现了这种化合物4，并提供了它具有硫醇结构的明确证据（即巯基）4-碳α-氨基酸：HSCH 2CH 2CH（NH 2）COOH。5同型半胱氨酸的对称二硫化物被称为“同型胱氨酸”，两个名称都是
In recent years, there has been an upsurge of interest in elevation of the plasma concentration of homocysteine and closely related metabolites as an independent risk factor for cardiovascular disease (reviewed, for example, in References 1 through 3). Homocysteine itself is a thiol-(sulfhydryl-) containing amino acid, but in normal human plasma and other tissues, a variety of related disulfide derivatives may be present. Different authors have written about these compounds and their effects by using differing terminologies. To promote clarity of meaning and to minimize uncertainty, perhaps even confusion, it is important that each article discussing these compounds either defines explicitly the terms and/or abbreviations used or cites a prior publication in which such definitions are provided. Optimally, a more uniform consensus terminology will be developed and adopted by the field. This article describes very briefly the structures of the relevant compounds and sets forth terms and abbreviations that, it is hoped, may provide a basis for such a consensus.The word “homocysteine” was used first by Du Vigneaud and coworkers 65 years ago when they discovered this compound4 and provided definitive proof that it had the structure of a thiol (ie, sulfhydryl) 4-carbon α-amino acid: HSCH2CH2CH (NH2) COOH. 5 The symmetrical disulfide of homocysteine was termed “homocystine,” both names being