In Children and Youth with Mild and Moderate Traumatic Brain Injury, Glial Fibrillary Acidic Protein Out-Performs S100b in Detecting Traumatic Intracranial Lesions on Computed Tomography
In Children and Youth with Mild and Moderate Traumatic Brain Injury, Glial Fibrillary Acidic Protein Out-Performs S100b in Detecting Traumatic Intracranial Lesions on Computed Tomography
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DOI：
10.1089/neu.2015.3869
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发表时间：
2016-01-01
影响因子：
4.2
通讯作者：
Zonfrillo, Mark
中科院分区：
文献类型：
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作者：
Papa, Linda;Mittal, Manoj K.;Zonfrillo, Mark
在成人中，胶质细胞酸性蛋白（GFAP）已被证明在检测轻度创伤性脑损伤（TBI）的计算机断层扫描（CT）颅内病变方面优于S100。本研究探讨了GFAP和S100在CT上检测创伤儿童和青少年颅内病变的能力。这项前瞻性队列研究在两个儿科和一个成人1级创伤中心招募了创伤后的儿童和青少年的便利样本，包括有和没有头部创伤的儿童和青少年。在损伤后6小时内采集血清样本。主要结局是CT扫描显示存在创伤性颅内病变。入组了155例儿科创伤患者，114例（74%）有头部创伤，41例（26%）无头部创伤。在接受头部CT检查的92例患者中，8例（9%）有颅内病变。用于区分头部创伤和非头部创伤的GFAP和S100的受试者工作特征曲线下面积（AUC）分别为0.84（0.77-0.91）和0.64（0.55-0.74; p
In adults, glial fibrillary acidic protein (GFAP) has been shown to out-perform S100 in detecting intracranial lesions on computed tomography (CT) in mild traumatic brain injury (TBI). This study examined the ability of GFAP and S100 to detect intracranial lesions on CT in children and youth involved in trauma. This prospective cohort study enrolled a convenience sample of children and youth at two pediatric and one adult Level 1 trauma centers following trauma, including both those with and without head trauma. Serum samples were obtained within 6h of injury. The primary outcome was the presence of traumatic intracranial lesions on CT scan. There were 155 pediatric trauma patients enrolled, 114 (74%) had head trauma and 41 (26%) had no head trauma. Out of the 92 patients who had a head CT, eight (9%) had intracranial lesions. The area under the receiver operating characteristic curve (AUC) for distinguishing head trauma from no head trauma for GFAP was 0.84 (0.77-0.91) and for S100 was 0.64 (0.55-0.74; p