Localized delivery of carbon monoxide
Localized delivery of carbon monoxide
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DOI：
10.1016/j.ejpb.2016.11.002
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发表时间：
2017-09-01
影响因子：
4.9
通讯作者：
Meinel, Lorenz
中科院分区：
文献类型：
--
作者：
Steiger, Christoph;Hermann, Cornelius;Meinel, Lorenz
血红素加氧酶（HO）/一氧化碳（CO）系统是一个生理反馈回路，协调各种细胞保护作用，以响应细胞应激。由于非靶向、全身给药后高CO-血红蛋白形成会危及成功的CO治疗（由于这种生物屏障），因此CO的治疗用途受到安全性挑战的阻碍。另一个警告是使用含有毒理学关键过渡金属的CO释放分子。一个新兴的本地交付的方法来解决这些问题，最近已经推出，并提供了令人兴奋的新的起点，将迷人的临床前潜力的CO转化为临床环境，这篇综述将讨论这些方法和链接到未来的交付策略，旨在建立CO作为一个安全有效的药物的明天。(c)© 2016 Elsevier B. V.版权所有。
The heme oxygenase (HO)/carbon monoxide (CO) system is a physiological feedback loop orchestrating various cell-protective effects in response to cellular stress. The therapeutic use of CO is impeded by safety challenges as a result of high CO-Hemoglobin formation following non-targeted, systemic administration jeopardizing successful CO therapies as of this biological barrier. Another caveat is the use of CO Releasing Molecules containing toxicologically critical transition metals. An emerging number of local delivery approaches addressing these issues have recently been introduced and provide exciting new starting points for translating the fascinating preclinical potential of CO into a clinical setting, This review will discuss these approaches and link to future delivery strategies aiming at establishing CO as a safe and effective medication of tomorrow. (c) 2016 Elsevier B.V. All rights reserved.