Epidemiological perspectives for the development of future diagnostic systems
Epidemiological perspectives for the development of future diagnostic systems
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DOI：
10.1159/000065137
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发表时间：
2002-03-01
期刊：
影响因子：
3.6
通讯作者：
Kessler, RC
中科院分区：
文献类型：
--
作者：
Kessler, RC
流行病学数据的诊断修订的三种用途的建议。(1)对社区病例进行心理测量学分析，对症状的严重程度进行全方位的分析，可以帮助确定是否真正的离散疾病实体是特定症状特征的基础。(2)外部验证器的分析;在社区样本中可以帮助选择最佳的临界点来定义诊断标准。(3)在进行昂贵的实验性治疗试验之前，临床流行病学研究可以提供快速且相对便宜的初步检查，以确定基于差异治疗反应的非实验性证据的拟议亚型区分的可行性。如果能纠正一些妨碍以往研究的基本概念和方法上的缺陷，这三种流行病学研究将在未来的诊断修订中发挥比以往更重要的作用。版权所有（C）2002 S. Karger AG，巴塞尔。
Three uses of epidemiological data for diagnostic revisions are suggested. (1) Psychometric analysis of community cases over the full spectrum of symptom severity can help determine whether true discrete disease entities underlie particular symptom profiles. (2) Analysis of external validators; in community samples can help select optimal cut-points for defining diagnostic criteria. (3) Clinical epidemiological studies can provide quick and comparatively inexpensive preliminary checks, prior to carrying out expensive experimental treatment trials, on the plausibility of proposed subtyping distinctions based on nonexperimental evidence regarding differential treatment response. Correction of a number of basic conceptual and methodological flaws that have hampered previous studies would allow epidemiological research of these three sorts to play a much more important part in future diagnostic revisions than they have in past revisions. Copyright (C) 2002 S. Karger AG, Basel.