Interaction between Fibrillin Genotype and Blood Pressure and the Development of Aneurysmal Disease a
Interaction between Fibrillin Genotype and Blood Pressure and the Development of Aneurysmal Disease a
复制标题
原纤维蛋白基因型与血压之间的相互作用以及动脉瘤疾病的发展
DOI：
--
复制
发表时间：
1996
影响因子：
5.2
通讯作者：
A. Henney
中科院分区：
文献类型：
--
作者：
J. Powell;S. MacSweeney;R. Greenhalgh;R. Turner;A. Henney
关于腹主动脉瘤（AAA）是否由动脉粥样硬化引起或是否有很强的遗传病因的争论仍在继续。我们已经研究了这一假设，即风险因素可能是最强的患者与全身性脑血管疾病。我们筛选了232例连续腹主动脉瘤患者的腘动脉瘤，并调查了这些患者的心血管和遗传风险因素。超声检查显示24/232例（10%）患者存在腘动脉瘤。多变量分析确定了与腘动脉瘤相关的4个独立因素：年龄（p = 0.013）、身高（p = 0.017）、甘油三酯浓度（p = 0.009）和收缩压（p = 0.037）。在AAA患者中，通过串联重复序列多态性确定，存在与收缩压和脉压显著相关的β 1蛋白-1基因型。与最高压力相关的基因型在腘动脉瘤患者中明显更常见，p = 0.03。根据这些发现，我们调查了245名年龄在50-61岁的健康人群中，Escherin-1基因型与血压之间是否存在关联。我们再次发现，在p53基因型和脉压之间存在显著关联，p = 0.003。我们认为，一个强有力的相互作用之间发生的基因型和血压，这有助于发展中国家的疾病。
Debate as to whether abdominal aortic aneurysms (AAA) are caused by atherosclerosis or whether they have a strong genetic etiology continues. We have investigated the hypothesis that risk factors are likely to be strongest in patients with generalized aneurysmal disease. We screened 232 consecutive AAA patients for popliteal aneurysm and investigated cardiovascular and genetic risk factors in these patients. Ultrasonography demonstrated the presence of a popliteal aneurysm in 24 of 232 (10%) patients. Multivariate analysis identified four independent factors associated with popliteal aneurysm: age (p = 0.013), height (p = 0.017), triglyceride concentration (p = 0.009), and systolic blood pressure (p = 0.037). In the AAA patients a significant association of fibrillin-1 genotype was present, determined by a tandem repeat polymorphism, with both systolic and pulse pressure. The genotypes associated with the highest pressures were significantly more common among the patients with popliteal aneurysm, p = 0.03. Following these findings we investigated whether there was an association between fibrillin-1 genotype and blood pressure in a healthy population, 245 men aged 50-61 years. Again we found a significant association between fibrillin genotype and pulse pressure, p = 0.003. We suggest that a strong interaction occurs between fibrillin genotype and blood pressure which contributes to the development of aneurysmal disease.
影响因子：
9.8
作者：
U. Francke;M. Berg;K. Tynan;T. Brenn;Wanguo Liu;T. Aoyama;C. Gasner;D. Miller;H. Furthmayr
通讯作者：
U. Francke;M. Berg;K. Tynan;T. Brenn;Wanguo Liu;T. Aoyama;C. Gasner;D. Miller;H. Furthmayr
DOI：
10.1172/jci116490
发表时间：
1993-06
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
G. Tromp;Yuli Wu;D. Prockop;S. Madhatheri;Caren Kleinert;J. Earley;J. Zhuang;Ö. Norrgård;Darling Rc;W. Abbott
通讯作者：
G. Tromp;Yuli Wu;D. Prockop;S. Madhatheri;Caren Kleinert;J. Earley;J. Zhuang;Ö. Norrgård;Darling Rc;W. Abbott