The FN400 is functionally distinct from the N400
The FN400 is functionally distinct from the N400
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DOI：
10.1016/j.neuroimage.2012.07.047
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发表时间：
2012-11-15
期刊：
影响因子：
5.7
通讯作者：
Mecklinger, Axel
中科院分区：
文献类型：
--
作者：
Bridger, Emma K.;Bader, Regine;Mecklinger, Axel
FN 400是指由旧项目和新项目引起的ERP之间的早期中前部分布差异，其运作方式与基于熟悉度的识别的神经标记一致。FN 400和后来的ERP回忆指数之间的双重分离提供了一些最令人信服的证据，支持迄今为止的双过程模型。然而，最近有人声称，没有证据表明FN 400在功能上不同于内隐语义启动的N400指数（Voss，J.，和Federmeier，K.，FN 400电位在功能上与N400电位相同，并且反映了识别测试期间的语义处理，Psychophysiology，48，532-546，2011），挑战了基于该效应做出的推断。我们认为，采用这种说法的设计是有缺陷的，因为它包括一个语义启动操纵嵌入在一个连续的识别测试，使识别对比混淆语义过程中的一些方式。在这里，ERPs记录的设计，避免这些混淆，采用语义启动范式，也作为编码阶段的惊喜随后的识别测试阶段。在语义启动任务中引起的N400效应表现出建立的中央-顶叶最大值，而在识别测试中正确响应旧的和新的ERP之间的差异是最大的额叶网站在同一时间窗口。当直接比较的电生理相关的语义启动和情景识别记录在一个范例中，这两个是不混淆，FN 400反映了一个定性不同的效果从N400。(C)2012 Elsevier Inc. All rights reserved.
The FN400 refers to the early midfrontally-distributed difference between ERPs elicited by old and new items, which operates in a way consistent with a neural marker of familiarity-based recognition. Double dissociations between the FN400 and a later ERP index of recollection provide some of the most compelling evidence in support of dual-process models to date. It has recently been claimed, however, that there is no evidence that the FN400 is functionally distinct from the N400 index of implicit semantic priming (Voss, J., and Federmeier, K., FN400 potentials are functionally identical to N400 potentials and reflect semantic processing during recognition testing, Psychophysiology, 48, 532-546, 2011), challenging inferences made on the basis of this effect. We argue that the design employed to make this claim is flawed because it comprised a semantic priming manipulation embedded within a continuous recognition test which enabled recognition contrasts to be confounded by semantic processes in a number of ways. Here, ERPs were recorded from a design which avoided these confounds by employing a semantic priming paradigm which also served as the encoding phase for a surprise subsequent recognition test phase. An N400 effect elicited in the semantic priming task demonstrated the established centro-parietal maximum, whereas the difference between correctly responded to old and new ERPs in the recognition test was maximal over frontal sites in the same time window. When direct comparisons of the electrophysiological correlates of semantic priming and episodic recognition are recorded in a paradigm in which the two are not confounded, the FN400 reflects a qualitatively distinct effect from the N400. (C) 2012 Elsevier Inc. All rights reserved.