Geranylgeraniol is a potent inducer of apoptosis in tumor cells.
Geranylgeraniol is a potent inducer of apoptosis in tumor cells.
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香叶基香叶醇是肿瘤细胞凋亡的有效诱导剂。
DOI：
10.1093/oxfordjournals.jbchem.a124695
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发表时间：
1995
影响因子：
2.7
通讯作者：
K. Nakaya
中科院分区：
文献类型：
--
作者：
H. Ohizumi;Y. Masuda;S. Nakajo;I. Sakai;S. Ohsawa;K. Nakaya
我们筛选了多种类异戊二烯，寻找人类白血病HL-60细胞的凋亡诱导剂，从HL-60细胞的DNA片段判断，发现GGO（香叶醇）具有最有效的凋亡诱导活性。GGO的诱导凋亡活性具有浓度和时间依赖性。GGO可选择性抑制HL-60细胞的DNA合成。除HL-60细胞外，GGO还可诱导多种肿瘤细胞系凋亡，包括人髓系多潜能白血病K562、淋巴母细胞白血病Molt3和结肠癌腺癌COLO320 DM。
We screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol) had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.