Roles of RUNX Complexes in Immune Cell Development
Roles of RUNX Complexes in Immune Cell Development
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DOI：
10.1007/978-981-10-3233-2_24
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Taniuchi, Ichiro
中科院分区：
文献类型：
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作者：
Ebihara, Takashi;Seo, Wooseok;Taniuchi, Ichiro
在造血过程中，干细胞经过连续几轮的细胞命运决定过程产生各种细胞。近二十年来的研究表明，Runx转录因子家族成员参与多种类型造血细胞的分化。随着进化保护，Runx家族被认为是造血的祖先调节器之一。可以想象，Runx家族参与塑造免疫系统，然后由先天和获得性淋巴样细胞组成的脊椎动物。在本章中，我们将首先总结Runx蛋白在T淋巴细胞和b淋巴细胞发育过程中的作用。T淋巴细胞和b淋巴细胞是在进化后期出现的，由于DNA重组过程而表达抗原特异性受体。我们还讨论了最近的发现，揭示了Runx在先天淋巴样细胞（ILCs）分化过程中的功能。
During hematopoiesis, a variety of cells are generated from stem cells through successive rounds of cell fate determination processes. Studies in the last two decades have demonstrated the involvement of Runx transcription factor family members in differentiation of multiple types of hematopoietic cells. Along with evolutionary conservation, the Runx family is considered to be one of the ancestral regulators of hematopoiesis. It is conceivable that the Runx family is involved in shaping the immune system, which is then comprised of innate and acquired lymphoid cells in vertebrates. In this chapter, we will first summarize roles of Runx proteins during the development of T- and B-lymphocytes, which appeared later during evolution and express antigen specific receptors as a result of DNA recombination processes. We also discuss the recent findings that have unraveled the functions of Runx during differentiation of innate lymphoid cells (ILCs).