Mosquito Defense Strategies against Viral Infection.
Mosquito Defense Strategies against Viral Infection.
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DOI：
10.1016/j.pt.2015.09.009
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发表时间：
2016-03
影响因子：
9.6
通讯作者：
Xiao X
中科院分区：
文献类型：
--
作者：
Cheng G;Liu Y;Wang P;Xiao X
蚊媒病毒性疾病是全球健康的一个主要问题，并给许多国家造成重大经济损失。作为天然媒介，蚊子非常容易并允许系统性和持续性虫媒病毒感染。有趣的是，蚊子组织中持续的病毒传播既不会导致严重的病理后遗症，也不会损害媒介行为或寿命，这表明蚊子已经进化出耐受持续感染的机制，并开发出有效的抗病毒策略，将病毒复制限制在非致病水平。在这里，我们概述了了解蚊子抗病毒免疫的最新进展以及蚊子控制特定组织中病毒感染的策略的进展。
Mosquito-borne viral diseases are a major concern of global health and result in significant economic losses in many countries. As natural vectors, mosquitoes are very permissive to and allow systemic and persistent arbovirus infection. Intriguingly, persistent viral propagation in mosquito tissues neither results in dramatic pathological sequelae nor impairs the vectorial behavior or lifespan, indicating that mosquitoes have evolved mechanisms to tolerate persistent infection and developed efficient antiviral strategies to restrict viral replication to non-pathogenic levels. Here, we provide an overview of recent progress in understanding mosquito antiviral immunity and advances in the strategies by which mosquitoes control viral infection in specific tissues.