Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.
Reversibly Modulating the Blood-Brain Barrier by Laser Stimulation of Molecular-Targeted Nanoparticles.
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DOI：
10.1021/acs.nanolett.1c02996
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发表时间：
2021-11-24
期刊：
影响因子：
10.8
通讯作者：
Qin Z
中科院分区：
文献类型：
--
作者：
Li X;Vemireddy V;Cai Q;Xiong H;Kang P;Li X;Giannotta M;Hayenga HN;Pan E;Sirsi SR;Mateo C;Kleinfeld D;Greene C;Campbell M;Dejana E;Bachoo R;Qin Z
血脑屏障(BBB)具有很高的选择性，是中枢神经系统和循环之间的接口。虽然血脑屏障对维持大脑稳态至关重要，但它对药物输送来说是一个巨大的挑战。在这里，我们合成了专门针对紧密连接的金纳米颗粒(AuNPs)，并证明了静脉注射后经颅皮秒激光刺激这些AuNPs会增加血脑屏障的通透性。血脑屏障通透性的变化可以由激光强度分级，是完全可逆的，并且涉及到细胞旁扩散的增加。血脑屏障调节不会导致自发血管运动或神经血管单位结构的显著中断。这一策略允许免疫球蛋白和病毒基因治疗载体以及载货脂质体进入。我们预计这种纳米技术将对光线或光纤应用可到达的组织区域有用，并为中枢神经系统的药物筛选和治疗干预开辟新的途径。
The blood–brain barrier (BBB) is highly selective and acts as the interface between the central nervous system and circulation. While the BBB is critical for maintaining brain homeostasis, it represents a formidable challenge for drug delivery. Here we synthesized gold nanoparticles (AuNPs) for targeting the tight junction specifically and demonstrated that transcranial picosecond laser stimulation of these AuNPs post intravenous injection increases the BBB permeability. The BBB permeability change can be graded by laser intensity, is entirely reversible, and involves increased paracellular diffusion. BBB modulation does not lead to significant disruption in the spontaneous vasomotion or the structure of the neurovascular unit. This strategy allows the entry of immunoglobulins and viral gene therapy vectors, as well as cargo-laden liposomes. We anticipate this nanotechnology to be useful for tissue regions that are accessible to light or fiberoptic application and to open new avenues for drug screening and therapeutic interventions in the central nervous system.
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影响因子：
4.1
作者：
Asquier, Nicolas;Bouchoux, Guillaume;Carpentier, Alexandre
通讯作者：
Carpentier, Alexandre
影响因子：
3.5
作者：
Busch, David R.;Davis, James;Floyd, Thomas F.
通讯作者：
Floyd, Thomas F.
影响因子：
16.2
作者：
Andreone BJ;Chow BW;Tata A;Lacoste B;Ben-Zvi A;Bullock K;Deik AA;Ginty DD;Clish CB;Gu C
通讯作者：
Gu C
影响因子：
17.1
作者：
Mantri Y;Jokerst JV
通讯作者：
Jokerst JV
影响因子：
12.7
作者：
Gurnik S;Devraj K;Macas J;Yamaji M;Starke J;Scholz A;Sommer K;Di Tacchio M;Vutukuri R;Beck H;Mittelbronn M;Foerch C;Pfeilschifter W;Liebner S;Peters KG;Plate KH;Reiss Y
通讯作者：
Reiss Y