Immune regulation by Tim-3.
Immune regulation by Tim-3.
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DOI：
10.12688/f1000research.13446.1
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kane LP
中科院分区：
文献类型：
--
作者：
Banerjee H;Kane LP
T细胞免疫球蛋白和粘蛋白结构域3（Tim-3）是一种跨膜蛋白，在小鼠和人类中已被证明具有各种功能，在上下文依赖性的方式。因此，Tim-3与抑制和共刺激功能相关，部分取决于特定的细胞类型和免疫应答过程。虽然Tim-3最初在T细胞上描述，但现在已知它由免疫系统内的淋巴和非淋巴细胞甚至非免疫细胞表达。此外，尽管Tim-3被广泛认为是免疫的负调节剂，但在最近的研究中已显示其对骨髓和淋巴细胞（包括T细胞）具有正功能。Tim-3通常在肿瘤和慢性感染中耗尽的T细胞上以高水平表达，并且可能与其他所谓的“检查点”分子如PD-1发生串扰。因此，Tim-3已经成为一个可能的治疗靶点，正在临床前和临床上积极探索。然而，最近的研究表明，与该领域的其他靶点相比，这种蛋白质在体内的作用更为复杂。
T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both mice and humans has been shown to possess various functions in a context-dependent manner. Thus, Tim-3 has been associated with both inhibitory and co-stimulatory function, depending in part on the specific cell type and immune response course. Though originally described on T cells, Tim-3 is now known to be expressed by both lymphoid and non-lymphoid cells within the immune system and even by non-immune cells. In addition, though widely thought of as a negative regulator of immunity, Tim-3 has been shown in more recent studies to have a positive function on both myeloid and lymphoid cells, including T cells. Tim-3 is often expressed at a high level on exhausted T cells in tumors and chronic infection and may engage in crosstalk with other so-called “checkpoint” molecules such as PD-1. Thus, Tim-3 has emerged as a possible therapeutic target, which is being actively explored both pre-clinically and clinically. However, recent research suggests a more complex in vivo role for this protein, compared with other targets in this area.