Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats.
Reduction of CCK-8 binding in the nucleus of the solitary tract in unilaterally nodosectomized rats.
复制标题
单侧结节切除大鼠孤束核中 CCK-8 结合减少。
DOI：
10.1016/0006-8993(88)90675-0
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Ritter,RC
中科院分区：
文献类型：
--
作者：
Ladenheim,EE;Speth,RC;Ritter,RC
用125 I-CCK-8离体放射自显影法研究了单侧脑结切除大鼠和正常大鼠尾侧后脑的CCK-8结合部位。单侧nodosectomy造成了显着减少CCK-8结合在孤束尾侧内侧核（NST）的同侧的节点gangliosectomy。其他尾部后脑区域表现出CCK-8结合的检查没有发现在nodosectomized动物与对照组相比，结合的变化。提示该脑区的CCK受体可能位于迷走神经传入神经元的终末。
Cholecystokinin octapeptide (CCK-8) binding sites were examined in the caudal hindbrain of unilaterally nodosectomized and intact rats by in vitro autoradiography with125I-CCK-8. Unilateral nodosectomy caused a significant reduction in CCK-8 binding in the caudal medial nucleus of the solitary tract (NST) on the side ipsilateratal to the node gangliosectomy. Examination of other caudal hindbrain regions exhibiting CCK-8 binding did not reveal changes in binding in nodosectomized animals compared to controls. These findings suggest that the CCK receptors in this brain region may be located on terminals of vagal afferent neurons.