The HIV infection and immune activation: "to fight and burn".
The HIV infection and immune activation: "to fight and burn".
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DOI：
10.1007/s11908-005-0050-9
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发表时间：
2005-11-01
影响因子：
3.1
通讯作者：
Autran, Brigitte
中科院分区：
文献类型：
--
作者：
Appay, Victor;Boutboul, Francois;Autran, Brigitte
免疫激活是一种对病原体的正常免疫反应，现在被认为是HIV引起的CD4T细胞耗尽和免疫紊乱的主要驱动力。相比之下，其祖先病毒-猿猴免疫缺陷病毒的自然宿主通过阻止免疫激活和保持健康来适应这种病毒。这篇综述将侧重于证据表明，与艾滋病毒感染相关的免疫激活如何耗尽对艾滋病毒和免疫系统的免疫防御，从而导致免疫衰老和免疫缺陷，以及治疗如何打破这一恶性循环并最终导致死亡。
Immune activation, a normal immune reaction to pathogens, is now recognized as a major driving force of the CD4 T-cell depletion and immune disorders caused by HIV. By contrast, the natural hosts of its ancestor virus, simian immunodeficiency virus, have adapted to this virus by blocking immune activation and remaining healthy. This review will focus on evidence demonstrating how immune activation associated with HIV infection exhausts immune defenses to HIV as well as the immune system, thus leading to immunosenescence and immunodeficiency, and how treatment can disrupt this vicious and ultimately fatal circle.