Cancer wars: natural products strike back.
Cancer wars: natural products strike back.
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癌症战争：天然产品的反击。
DOI：
10.3389/fchem.2014.00020
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发表时间：
2014
影响因子：
5.5
通讯作者：
Désaubry LG
中科院分区：
文献类型：
--
作者：
Basmadjian C;Zhao Q;Bentouhami E;Djehal A;Nebigil CG;Johnson RA;Serova M;de Gramont A;Faivre S;Raymond E;Désaubry LG
天然产物历来是抗癌药物的主要来源，但在90年代，随着靶向治疗的出现，它们在制药公司中失去了青睐，靶向治疗依赖于抗体或通过高通量筛选识别的小合成分子。虽然靶向治疗极大地改善了一些癌症的治疗，但对许多实体瘤的益处仍然令人失望，这使人们对天然产品的兴趣重新燃起。随着2007年雷帕霉素获批，已有12种新型天然产物衍生物上市。本文综述了这些新型抗癌药物的发现和发展，强调了天然产物的特点和这一令人兴奋的药物发现领域的新趋势。
Natural products have historically been a mainstay source of anticancer drugs, but in the 90's they fell out of favor in pharmaceutical companies with the emergence of targeted therapies, which rely on antibodies or small synthetic molecules identified by high throughput screening. Although targeted therapies greatly improved the treatment of a few cancers, the benefit has remained disappointing for many solid tumors, which revitalized the interest in natural products. With the approval of rapamycin in 2007, 12 novel natural product derivatives have been brought to market. The present review describes the discovery and development of these new anticancer drugs and highlights the peculiarities of natural product and new trends in this exciting field of drug discovery.
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影响因子：
15
作者：
Chen, JC;Chen, XC;Zhu, JP
通讯作者：
Zhu, JP
影响因子：
46.9
作者：
Basu, P
通讯作者：
Basu, P
影响因子：
15
作者：
Bode, JW;Carreira, EM
通讯作者：
Carreira, EM
影响因子：
50.5
作者：
Bennouna, J;Fumoleau, P;Marty, A
通讯作者：
Marty, A
影响因子：
15
作者：
Dancik, Vlado;Seiler, Kathleen Petri;Young, Damian W.;Schreiber, Stuart L.;Clemons, Paul A.
通讯作者：
Clemons, Paul A.