Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy
Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy
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DOI：
10.1167/tvst.8.6.18
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发表时间：
2019-11-01
影响因子：
3
通讯作者：
Miller, John B.
中科院分区：
文献类型：
--
作者：
Cui, Ying;Zhu, Ying;Miller, John B.
目的：分析宽视野扫频源光学相干断层扫描血管造影（SS-OCTA）在糖尿病视网膜病变（DR）中的成像伪影和分割误差。方法：我们于2018年12月至2019年3月在马萨诸塞州眼耳进行了一项前瞻性观察性研究。包括增殖性糖尿病视网膜病变（PDR）、非增殖性糖尿病视网膜病变（NPDR）、无糖尿病视网膜病变（DR）的糖尿病患者和健康对照眼。所有患者均使用SS-OCTA成像，并使用蒙太奇血管造影（15 x 9 mm）进行分析。由两名分级员使用运动伪影评分（MAS）独立评价图像。结果：98例（136只眼）受试者均获得了蒙太奇图像，所有数据均用SPSS25.0统计软件包进行统计分析。DR分期越重，MAS越高（P < 0.05）。分割错误的发生率在健康组中为0%，在无DR组中为10.53%，在NPDR组中为10.00%，在PDR组中为50%。多因素回归分析显示，DR严重程度和干眼症是影响MAS的主要因素（P < 0.05）。有一些可修改的文物，可以纠正，以提高图像quality.Conclusions：宽场SS-OCTA评估视网膜微血管的变化，通过非侵入性技术，但区分真实的改变的文物是至关重要的准确解释。DR严重程度和干眼症与MAS相关。
Purpose: To analyze imaging artifacts and segmentation errors with wide-field swept-source optical coherence tomography angiography (SS-OCTA) in diabetic retinopathy (DR).Methods: We conducted a prospective, observational study at Massachusetts Eye and Ear from December 2018 to March 2019. Proliferative diabetic retinopathy (PDR), nonproliferative diabetic retinopathy (NPDR), diabetic patients with no diabetic retinopathy (DR), and healthy control eyes were included. All patients were imaged with a SS-OCTA and the Montage Angio (15 x 9 mm) was used for analysis. Images were independently evaluated by two graders using the motion artifact score (MAS). All statistical analyses were performed using SPSS 25.0 and R software.Results: One hundred thirty-six eyes in 98 participants with the montage image were included in the study. Patients with more severe stages of DR had higher MAS by trend test analysis (P < 0.05). The occurrence of segmentation error was 0% in the healthy group, 10.53% in the no DR group, 10.00% in the NPDR group, and 50% in the PDR group. Multivariate regression analysis showed that the severity of DR and dry eye were the major factors affecting MAS (P < 0.05). There were some modifiable artifacts that could be corrected to improve image quality.Conclusions: Wide field SS-OCTA assesses retinal microvascular changes by noninvasive techniques, yet distinguishing real alterations from artifacts is paramount to accurate interpretations. DR severity and dry eye correlated with MAS.