No association between ApoE and schizophrenia: Evidence of systematic review and updated meta-analysis
No association between ApoE and schizophrenia: Evidence of systematic review and updated meta-analysis
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DOI：
10.1016/j.schres.2015.08.031
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发表时间：
2015-12-01
影响因子：
4.5
通讯作者：
Manuel Hernandez-Alvarado, Mervyn
中科院分区：
文献类型：
--
作者：
Beatriz Gonzalez-Castro, Thelma;Alfonso Tovilla-Zarate, Carlos;Manuel Hernandez-Alvarado, Mervyn
简介：精神分裂症影响全球0.3%至2%的人口。在这种疾病的发展过程中，已经假定遗传因素起了作用。在病例对照和荟萃分析研究中，ApoE等基因与精神分裂症相关的神经发育有关，但结果仍不确定。因此，本研究的目的是通过荟萃分析探讨ApoE与精神分裂症之间的关系。材料和方法：通过检索PubMed和EBSCO数据库收集所有相关研究。计算具有95%置信区间的合并优势比来估计相关性。评估了以下模型：A) epsilon 4 vs epsilon 3， B) epsilon 4 vs epsilon 2， C) epsilon 4 vs epsilon 3+ epsilon 2， D)高加索种群和E)亚洲种群。采用EPIDAT 3.1软件进行统计学分析。结果：荟萃分析包括28项关联研究，其中包括4703名对照和3452名精神分裂症患者。等位基因e3在亚洲人群中具有显著的保护作用（OR = 0.73, 95% CI = 0.54-0.98）。在分析的其他模型和种群中没有观察到显著的关联。结论：我们的荟萃分析表明ApoE等位基因epsilon 3与亚洲人群精神分裂症之间存在保护性关联。(C) 2015年作者。Elsevier B.V.出版
Introduction: Schizophrenia affects between 0.3% and 2% of the worldwide population. A genetic contribution has been postulated in the development of this disorder. Genes such as ApoE have been implicated in the neurodevelopment associated with schizophrenia in case-control and meta-analysis studies, but the results remain inconclusive. Due to this, the aim of the present study was to explore the association between ApoE and schizophrenia through a meta-analysis.Material and methods: We collected all relevant studies by searching PubMed and EBSCO databases. The pooled odds ratios with 95% confidence intervals were calculated to estimate the association. The following models were evaluated: A) epsilon 4 vs epsilon 3, B) epsilon 4 vs epsilon 2, C) epsilon 4 vs epsilon 3+ epsilon 2, D) Caucasian population and E) Asian population. Statistical analyses were performed using EPIDAT 3.1 software.Results: The meta-analyses comprised 28 association studies, which included 4703 controls and 3452 subjects with schizophrenia. A significant protective effect was found for allele e3 in the Asian population (OR = 0.73, 95% CI = 0.54-0.98). No significant associations were observed in the other models and populations analyzed.Conclusions: Ourmeta-analysis suggests a protective association between ApoE allele epsilon 3 and schizophrenia in the Asian population. (C) 2015 The Authors. Published by Elsevier B.V.