Noninvasive measurement of iron: report of an NIDDK workshop
Noninvasive measurement of iron: report of an NIDDK workshop
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DOI：
10.1182/blood-2002-06-1723
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发表时间：
2003-01-01
期刊：
影响因子：
20.3
通讯作者：
Badman, DG
中科院分区：
文献类型：
--
作者：
Brittenham, GM;Badman, DG
2001年4月17日，国家糖尿病、消化和肾脏疾病研究所（NIDDK）举办了一次关于铁的非侵入性测量的国际研讨会，以评估目前的科学状况，并确定需要进一步研究的领域。研讨会的结论是，临床上显然需要定量、非侵入性、安全、准确且现成的测量体内储存铁的方法，以改善遗传性血色素沉着症、重型地中海贫血、镰状细胞病等疾病引起的铁超载患者的诊断和管理。、再生障碍性贫血和骨髓发育不良等。磁共振成像（MRI）可能提供了检查体内多余铁的三维分布的最佳可用技术，但需要进一步研究以开发定量测量的方法。生物磁阻抗测量法提供了唯一的非侵入性方法来测量组织铁存储，已被校准，验证，并在临床研究中使用，但目前所需的液氦冷却超导仪器的复杂性，成本和技术要求限制了该方法的临床使用。研讨会确定了基础和临床研究机会，以加深我们对铁的物理特性和铁毒性的理解，进一步研究MRI作为定量测定组织铁的方法，特别是在肝脏，心脏和大脑中，并开发改进的方法和更广泛使用的生物磁阻抗测量仪器。
An international workshop on the noninvasive measurement of iron was conducted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on April 17, 2001, to assess the current state of the science and to identify areas needing further investigation. The workshop concluded that a clear clinical need is evident for quantitative, noninvasive, safe, accurate, and readily available means of measuring body storage iron to improve the diagnosis and management of patients with iron overload from such disorders as hereditary hemochromatosis, thalassemia major, sickle cell disease, aplastic anemia, and myelodysplasia, among others. Magnetic resonance imaging (MRI) potentially provides the best available technique for examining the 3-dimensional distribution of excess iron in the body, but further research is needed to develop means of making measurements quantitative. Bio-magnetic susceptometry provides the only noninvasive method to measure tissue iron stores that has been calibrated, validated, and used in clinical studies, but the complexity, cost, and technical demands of the liquid-helium-cooled superconducting instruments required at present have restricted clinical access to the method. The workshop identified basic and clinical research opportunities for deepening our understanding of the physical properties of iron and iron toxicity, for further investigation of MRI as a method for quantitative determinations of tissue iron, especially in liver, heart and brain, and for development of improved methods and more widely available instrumentation for biomagnetic susceptometry.