Transformation of Polyoxins D, E, and F with Sodium Bisulfite
Transformation of Polyoxins D, E, and F with Sodium Bisulfite
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用亚硫酸氢钠转化多抗毒素 D、E 和 F
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
Saburô Suzuki
中科院分区：
文献类型：
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作者：
K. Shibuya;Michio Tanaka;Takeo Nanbata;K. Isono;Saburô Suzuki
以5-羧基尿嘧啶为核碱基的多抗霉素D、E和F与亚硫酸氢钠在pH 4.0下选择性地反应，导致容易的脱羧，以良好的产率得到相应的5，6-二氢尿嘧啶-6-磺酸盐和尿嘧啶型多抗霉素（多抗霉素L、M和K）。前者的化合物也转化为后者几乎定量与温和的碱处理。并对转化产物的生物活性进行了描述。
Polyoxins D, E, and F which possess 5-carboxyuracil as the nucleobase were reacted selectively with sodium bisulfite at pH 4.0 resulting in facile decarboxylation to afford corresponding 5,6-dihydrouracil-6-sulfonates and uracil type polyoxins (polyoxins L, M, and K) in good yield. The former compounds were also converted to the latter almost quantitatively with mild alkali treatment. Biological activities of the transformed compounds were described.