Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring.
Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring.
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DOI：
10.1007/s12170-013-0308-y
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发表时间：
2013-06
影响因子：
1.9
通讯作者：
Saftlas, Audrey F
中科院分区：
文献类型：
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作者：
Ryckman, Kelli K;Borowski, Kristi S;Parikh, Nisha I;Saftlas, Audrey F
代谢综合征是全球日益严重的问题，是II型糖尿病和心血管疾病等非传染性疾病的诱因。发展代谢综合征的特定组分的风险，如肥胖、高脂血症、高血压和空腹血糖升高，主要归因于环境压力，包括营养不良、缺乏锻炼和吸烟。然而，大型流行病学队列和实验动物模型支持“成人疾病的发育起源”假说，该假说认为成人代谢疾病的风险很大一部分是由围产期发生的暴露决定的。孕妇肥胖和怀孕期间并发症的发生率，如早产、先兆子痫和妊娠糖尿病继续上升。随着我们降低围产期发病率和死亡率的能力提高，长期代谢后果仍然不确定，这表明需要在这一领域进行进一步研究。
Metabolic syndrome is a growing problem globally, and is a contributor to non-communicable diseases such as type II diabetes and cardiovascular disease. The risk of developing specific components of the metabolic syndrome such as obesity, hyperlipidemia, hypertension, and elevated fasting blood sugar has been largely attributed to environmental stressors including poor nutrition, lack of exercise, and smoking. However, large epidemiologic cohorts and experimental animal models support the “developmental origins of adult disease” hypothesis, which posits that a significant portion of the risk for adult metabolic conditions is determined by exposures occurring in the perinatal period. Maternal obesity and the rate of complications during pregnancy such as preterm birth, preeclampsia, and gestational diabetes continue to rise. As our ability to reduce perinatal morbidity and mortality improves the long-term metabolic consequences remain uncertain, pointing to the need for further research in this area.