X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells
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CBA/HN 小鼠 X 连锁 B 淋巴细胞免疫缺陷。
DOI：
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发表时间：
1975
影响因子：
15.3
通讯作者：
W. Paul
中科院分区：
文献类型：
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作者：
I. Scher;A. Ahmed;D. Strong;A. Steinberg;W. Paul
本文报道了免疫缺陷CBA/HN小鼠及其F1后代脾细胞的组成和功能特性的研究。虽然胸腺非依赖性(B)淋巴细胞的数量和功能均出现异常，但所有涉及胸腺依赖性(T)淋巴细胞的研究均正常。因此，这些小鼠的免疫缺陷的x连锁性质归因于B淋巴细胞异常或缺失。讨论了这种缺陷的可能性质以及这些小鼠的免疫缺陷与某些人类x连锁免疫缺陷疾病的相似性。
A study of the composition and functional properties of spleen cells from the immune deficient CBA/HN mice and their F1 progeny is reported. While abnormalities were seen in both the numbers and function of thymus-independent (B) lymphocytes, all studies involving thymus- dependent (T) lymphocytes were normal. The X-linked nature of the immune defect in these mice was therefore attributed to abnormal or absent B lymphocytes. The possible nature of this defect and the similarity of the immune defect in these mice to certain human X-linked immunodeficiency diseases are discussed.