Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.
Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.
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DOI：
10.1016/j.pharmthera.2013.03.009
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发表时间：
2013-07
影响因子：
13.5
通讯作者：
Lindsey, Merry L.
中科院分区：
文献类型：
--
作者：
Halade, Ganesh V.;Jin, Yu-Fang;Lindsey, Merry L.
心肌梗死（MI）后的不良心脏重构仍然是充血性心力衰竭的重要原因。需要额外的和新的策略来提高我们预测，诊断或治疗重塑的能力。许多研究小组已经探索了单一和多种生物标志物策略，以确定重塑进展的诊断指标，这将提高我们及时准确识别高危个体的能力。更好的临床指标的确定应进一步导致更有效的预测和及时的治疗。基质金属蛋白酶（MMP-9）是一种潜在的心脏重塑的生物标志物，已被动物模型和临床研究所证实。在动物MI模型中，MMP-9表达显著增加，并且与炎症、糖尿病微血管并发症、细胞外基质降解和合成以及心功能障碍相关。临床研究还建立了MMP-9与MI后重塑和死亡率之间的关系，使MMP-9成为添加到多个生物标志物列表中的可行候选者。根据定义，近端生物标志物显示出与其靶疾病的密切关系，而远端生物标志物显示出非靶向疾病修饰结果。在这篇综述中，我们探讨了MMP-9作为心脏重塑的近端生物标志物和炎症的远端生物标志物的能力。我们总结了目前的分子基础和临床平台，使我们能够包括MMP-9作为生物标志物在这两个类别。
Adverse cardiac remodeling following myocardial infarction (MI) remains a significant cause of congestive heart failure. Additional and novel strategies that improve our ability to predict, diagnose, or treat remodeling are needed. Numerous groups have explored single and multiple biomarker strategies to identify diagnostic prognosticators of remodeling progression, which will improve our ability to promptly and accurately identify high-risk individuals. The identification of better clinical indicators should further lead to more effective prediction and timely treatment. Matrix metalloproteinase (MMP-9) is one potential biomarker for cardiac remodeling, as demonstrated by both animal models and clinical studies. In animal MI models, MMP-9 expression significantly increases and is linked with inflammation, diabetic microvascular complications, extracellular matrix degradation and synthesis, and cardiac dysfunction. Clinical studies have also established a relationship between MMP-9 and post-MI remodeling and mortality, making MMP-9 a viable candidate to add to the multiple biomarker list. By definition, a proximal biomarker shows a close relationship with its target disease, whereas a distal biomarker exhibits non-targeted disease modifying outcomes. In this review, we explore the ability of MMP-9 to serve as a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation. We summarize the current molecular basis and clinical platform that allow us to include MMP-9 as a biomarker in both categories.
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影响因子：
6
作者：
Fang, Lu;Du, Xiao-Jun;Dart, Anthony M.
通讯作者：
Dart, Anthony M.
影响因子：
37.8
作者：
Cipollone, F;Iezzi, A;Mezzetti, A
通讯作者：
Mezzetti, A
DOI：
10.1152/ajpheart.2001.281.3.h987
发表时间：
2001-09-01
影响因子：
4.8
作者：
Etoh, T;Joffs, C;Spinale, FG
通讯作者：
Spinale, FG
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DOI：
10.1161/circgenetics.111.959981
发表时间：
2011-08-01
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Chiao YA;Dai Q;Zhang J;Lin J;Lopez EF;Ahuja SS;Chou YM;Lindsey ML;Jin YF
通讯作者：
Jin YF
DOI：
10.1161/01.atv.0000197795.56960.64
发表时间：
2006-02-01
影响因子：
8.7
作者：
de Nooijer, R;Verkleij, CJN;Biessen, EAL
通讯作者：
Biessen, EAL