Cell-cell communication by quorum sensing and dimension-reduction
Cell-cell communication by quorum sensing and dimension-reduction
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DOI：
10.1007/s00285-006-0024-z
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发表时间：
2006-10-01
影响因子：
1.9
通讯作者：
Hartmann, Anton
中科院分区：
文献类型：
--
作者：
Mueller, Johannes;Kuttler, Christina;Hartmann, Anton
如果种群密度超过一定的阈值，一些细菌分类群会改变它们的行为。这种现象是细菌之间的通信系统的结果，称为群体感应（QS）。到目前为止，这一现象大多是在人口水平上建模的。然而，新的实验技术允许单细胞分析。我们介绍了一种建模方法，用于描述这个QS系统，包括讨论的监管网络和它的行为。基于这个单细胞模型，我们开发和分析一个空间结构的细胞群体模型。特别注意的缩放行为w.r.t.细胞大小（导致一个近似定理的固定解决方案）和其后果的解释细胞通信（QS与扩散传感）。最后，我们将建模方法应用于空间结构化的实验数据。
Several bacterial taxa change their behavior if the population density exceeds a certain threshold. This phenomenon is the consequence of a communication system between the bacteria and is called quorum sensing (QS). Up to now, this phenomenon is mostly modeled at population level. However, new experimental techniques allow for single cell analysis. We introduce a modeling approach for the description of this QS system, including a discussion of the regulatory network and its bistable behavior. Based on this single-cell model we develop and analyze a spatially structured model for a cell population. Special attention is given to the scaling behavior w.r.t. the cell size (leading to an approximation theorem for stationary solutions) and its consequences for the interpretation of cell communication (QS versus diffusion sensing). Concluding, we apply the modeling approach to spatially structured experimental data.