Effect of niacin on FGF23 concentration in chronic kidney disease.
Effect of niacin on FGF23 concentration in chronic kidney disease.
复制标题
烟酸对慢性肾脏病中 FGF23 浓度的影响。
DOI：
10.1159/000362424
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发表时间：
2014
影响因子：
4.2
通讯作者：
Ix JH
中科院分区：
文献类型：
--
作者：
Rao M;Steffes M;Bostom A;Ix JH
Elevated serum phosphorus and FGF23 are independent cardiovascular risk factors in patients with chronic kidney disease (CKD). In a randomized controlled trial (RCT) of patients with dyslipidemia assigned to either extended release niacin (ERN) alone, ERN combined with the selective prostaglandin D2 receptor subtype 1 inhibitor laropiprant (ERN-L) or placebo, niacin lowered serum phosphorus; however it is not known if it lowers FGF23 concentrations. Ancillary study to a multicenter, randomized, double-blind, placebo-controlled, trial among patients with dyslipidemia and eGFR 30–74 ml/min/1.73m2. Participants were randomized to ERN-L (N=162), ERN (N=97), or placebo (N=68) in a 3:2:1 ratio for 24-weeks. The primary outcome was change in serum FGF23 concentrations; and secondary outcomes were change in other mineral metabolism parameters. Both the ERN and ERN-L groups showed significant declines in serum phosphorus, calcium and calcium*phosphorus product at 24 weeks compared to placebo. A significant decline from baseline (10.9%, p< 0.01) in serum FGF23 concentration was observed in the ERN group compared to placebo, but not in the ERN-L group compared to placebo (p=0.36 and 0.97 for ERN-L and placebo respectively), despite equivalent declines in serum phosphorus. Similarly, the most marked declines in PTH occurred in the ERN only group vs. placebo; no change in PTH was observed in the ERN-L group. In this ancillary study of hyperlipidemic patients with eGFR 30–74ml/min/1.73m2), extended release niacin alone, but not in combination with laropiprant, lowered FGF23 and PTH concentrations. If confirmed, niacin may provide a novel strategy to decrease phosphorus, FGF23, and PTH concentrations in patients with CKD.
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DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
6.1
作者：
Eto, N;Miyata, Y;Yamashita, T
通讯作者：
Yamashita, T
影响因子：
4.8
作者：
Foley, Robert N.;Collins, Allan J.;Kalra, Philip A.
通讯作者：
Kalra, Philip A.
DOI：
10.1038/ki.2009.188
发表时间：
2009-08-01
期刊：
Kidney international. Supplement
影响因子：
--
作者：
通讯作者：
--
影响因子：
13.6
作者：
Kestenbaum, B;Sampson, JN;Andress, DL
通讯作者：
Andress, DL