The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.
The Ah Receptor from Toxicity to Therapeutics: Report from the 5th AHR Meeting at Penn State University, USA, June 2022.
复制标题
DOI：
10.3390/ijms24065550
复制
发表时间：
2023-03-14
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
芳烃受体 (AHR) 是一种低分子量分子信号传感器，这些信号源自环境暴露、微生物组和宿主代谢。在检查人为化学暴露的初步研究的基础上，微生物、饮食和宿主代谢来源的 AHR 配体列表不断增加，并为这种神秘受体的功能提供了重要线索。现在已证明 AHR 直接参与影响宿主稳态、慢性疾病发展和对毒性损伤反应的许多生化途径。随着这一研究领域的不断发展，AHR 显然是癌症、代谢性疾病、皮肤病和自身免疫性疾病的重要新靶标。这次会议试图涵盖正在进行的基础和应用研究的范围，以解决我们对该受体的基础知识在治疗结果上的可能应用。
The aryl hydrocarbon receptor (AHR) is a sensor of low-molecular-weight molecule signals that originate from environmental exposures, the microbiome, and host metabolism. Building upon initial studies examining anthropogenic chemical exposures, the list of AHR ligands of microbial, diet, and host metabolism origin continues to grow and has provided important clues as to the function of this enigmatic receptor. The AHR has now been shown to be directly involved in numerous biochemical pathways that influence host homeostasis, chronic disease development, and responses to toxic insults. As this field of study has continued to grow, it has become apparent that the AHR is an important novel target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting attempted to cover the scope of basic and applied research being performed to address possible applications of our basic knowledge of this receptor on therapeutic outcomes.
影响因子：
6.1
作者：
通讯作者：
--