Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography.
Caffeine Delays Retinal Neurovascular Coupling during Dark to Light Adaptation in Healthy Eyes Revealed by Optical Coherence Tomography Angiography.
复制标题
光学相干断层扫描血管造影显示，健康眼睛在暗到光适应过程中，咖啡因会延迟视网膜神经血管耦合。
DOI：
10.1167/iovs.61.4.37
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发表时间：
2020
影响因子：
4.4
通讯作者：
Fawzi,AmaniA
中科院分区：
文献类型：
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作者：
Zhang,YiStephanie;Lee,HeeEun;Kwan,ChangyowC;Schwartz,GregoryW;Fawzi,AmaniA
目的：本研究的目的是探讨急性影响的咖啡因对视网膜血流动力学在黑暗中的光适应使用光学相干断层扫描血管造影术（OCTA.Methods）：13名健康人（13只眼）进行OCTA成像后，黑暗适应和在重复的时间间隔过渡到环境光在两个成像会话：控制和后ingrophic 200毫克的咖啡因。我们分析了浅表毛细血管丛（SCP）、中毛细血管丛（MCP）和深毛细血管丛（DCP）的血管旁血管密度（VD）和校正血流指数（AFI），以及SCP的血管长度密度（VLD）。在调整了年龄、屈光不正和扫描质量后，我们比较了对照组和咖啡因组的参数。结果：在黑暗中，咖啡因组的MCP VD显著降低（− 2.63±1.28%）。在过渡到光照的过程中，最初，与对照组相比，咖啡因组的DCP VD增加（12.55±2.52%），而SCP VD显著降低（-2.09 ±0.91%）。光照15分钟后，DCP VD逆转并显著降低（− 5.45±2.62%），而MCP VD增加（4.65±1.74%）。AFI或VLD.Conclusions：我们表明，总体而言，咖啡因会导致延迟的血管反应的趋势，在所有三个黄斑毛细血管丛响应于环境光。而MCP在黑暗中收缩，在从黑暗到光明的过渡期间，DCP的初始延迟随后是长时间的收缩，SCP的收缩随后是缓慢的扩张。我们认为这些延迟的血管反应可能存在毛细血管缺血的潜在风险。
Purpose: The purpose of this study was to investigate the acute effects of caffeine on retinal hemodynamics during dark to light adaptation using optical coherence tomography angiography (OCTA).Methods: Thirteen healthy individuals (13 eyes) underwent OCTA imaging after dark adaptation and at repeated intervals during the transition to ambient light in two imaging sessions: control and after ingesting 200 mg of caffeine. We analyzed the parafoveal vessel density (VD) and adjusted flow index (AFI) of the superficial capillary plexus (SCP), middle capillary plexus (MCP), and deep capillary plexus (DCP), as well as the vessel length density (VLD) of the SCP. After adjusting for age, refractive error, and scan quality, we compared parameters between control and caffeine conditions.Results: In the dark, MCP VD decreased significantly after caffeine (− 2.63±1.28%). During the transition to light, initially, DCP VD increased (12.55±2.52%), whereas SCP VD decreased (− 2.09±0.91%) significantly with caffeine compared to control. By 15 minutes in light, DCP VD reversed and was significantly decreased (− 5.45±2.62%), whereas MCP VD increased (4.65±1.74%). There were no differences in AFI or VLD.Conclusions: We show that, overall, caffeine causes a trend of delayed vascular response in all three macular capillary plexuses in response to ambient light. Whereas the MCP is constricted in the dark, during the transition from dark to light, there is initially delay followed by prolonged constriction of the DCP and constriction followed by slow dilation of the SCP. We posit that these delayed vascular responses may present potential risk of capillary ischemia.