Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study.
Relationship between prognosis of papillary thyroid carcinoma patient and age: a retrospective single-institution study.
复制标题
甲状腺乳头状癌患者预后与年龄的关系：单机构回顾性研究。
作者：
Yasuhiro Ito;A. Miyauchi;M. Kihara;Y. Takamura;Kaoru Kobayashi;A. Miya
年龄是影响甲状腺乳头状癌预后的重要因素。在本研究中，我们研究了7个亚群的PTC患者（20岁及以下、21-30岁、31-40岁、41-50岁、51-60岁、61-70岁和70岁以上）在发病时没有远处转移或有辐射暴露史的预后差异。20岁以下和60岁以上患者的淋巴结复发率较高。60岁以上患者的远处复发率和癌死亡率显著升高。随着年龄的增长，甲状腺外肿大的发生率明显增加，但大淋巴结转移或结外肿大的发生率在7个亚组之间差异不大。Kaplan-Meier法显示，20岁以下和60岁以上患者的淋巴结复发率较低。在具有或不具有这些侵袭性特征的PTC患者系列中，60岁以上患者的远端无复发和病因特异性生存率较差。提示：1)20岁及以下患者和60岁以上患者淋巴结复发率较高；2)无论PTC初始手术时的临床病理特征如何，60岁以上患者的预后较差，包括远端无复发生存和病因特异性生存。
Age is an important prognostic factor in papillary thyroid carcinoma (PTC). In this study, we investigated the difference in prognosis of 7 subsets of PTC patients without distant metastasis at presentation or a history of radiation exposure (20 years or younger, 21-30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years, and older than 70 years). The lymph node recurrence rate was high in patients 20 years or younger and those older than 60 years. Distant recurrence and carcinoma death rates significantly elevated in patients older than 60 years. The incidence of significant extrathyroid extension markedly increased with age, although that of large node metastasis or extranodal tumor extension did not differ much among the 7 subsets. With the Kaplan-Meier method, lymph node recurrence rate was poor in patients 20 years or younger and in those older than 60 years. Poor distant recurrence-free and cause specific survivals of patients older than 60 years were identified in the series of PTC patients with and without these aggressive features. It is therefore suggested that 1) Lymph node recurrence rate was high in patients 20 years or younger and those older than 60 years and 2) prognosis, including distant recurrence-free survival and cause-specific survival, of patients older than 60 years was poor regardless of clinicopathological features of PTC at initial surgery.