Feline oncornavirus-associated cell membrane antigen. III. Antibody titers in cats from leukemia cluster households.
Feline oncornavirus-associated cell membrane antigen. III. Antibody titers in cats from leukemia cluster households.
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猫冠状病毒相关细胞膜抗原。
DOI：
10.1093/jnci/54.3.637
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
A. Sliski
中科院分区：
文献类型：
--
作者：
M. Essex;R. Jakowski;W. Hardy;S. Cotter;P. Hess;A. Sliski
对生活在已知自然暴露于猫白血病病毒（FeLV）环境中的182只健康猫的血清样本进行了检测，以检测猫冠状病毒相关细胞膜抗原抗体的存在。其中包括138只来自白血病“群集”家庭的猫。根据外周血白细胞和血小板中的病毒群特异性抗原（gasa）测定，这些猫先前显示出FeLV感染频率大大增加。已知暴露于FeLV的182只猫的几何平均抗体滴度为4.69，比来自同一地理区域但未暴露于FeLV的健康宠物猫的平均滴度高出4倍多。在暴露环境中，大约92%的猫对FeLV gsa或猫冠状病毒相关细胞膜抗原（FOCMA）抗体呈阳性，gsa阳性猫的FOCMA抗体几何平均滴度低于gsa阴性猫。在暴露环境中，不同性别的猫没有发现差异，但与年轻组相比，5岁及以上的猫观察到更高的几何平均抗体滴度。这些结果证明，先前关于群集家庭中白血病发病率增加的报道并不仅仅是由于偶然性，而是由于FeLV环境中猫的感染率增加。此外，他们认为FeLV的水平传播在拥挤的条件下非常有效，并且大多数自然暴露于病毒的猫会引起积极的免疫反应。
Serum samples from 182 healthy cats residing in environments known to have a natural exposure to feline leukemia virus (FeLV) were examined for the presence of antibody to the feline oncornavirus-associated cell membrane antigen. The number included 138 cats from leukemia-"cluster" households. Such cats previously showed greatly increased frequencies of FeLV infection, as determined by the virus group-specific antigen (gasa) in peripheral blood leukocytes and platelets. The geometric mean antibody titer for all 182 cats with known exposure to FeLV was 4.69, more than four times higher than the mean titer for healthy pet cats from the same geographic areas but with no known FeLV exposure. About 92 percent of the cats in exposure environments were positive for FeLV gsa or feline oncornavirus-associated cell membrane antigen (FOCMA) antibody, and gsa-positive cats had lower FOCMA antibody geometric mean titers than gsa-negative cats. In the exposure environments, no differences were seen for cats of different sexes, but a higher geometric mean antibody titer was observed for cats 5 years and over when compared to younger groups. These results prove that previous reports of increased incidences of leukemia in cluster households were not due to chance alone, but rather to increased infection rates of cats in the FeLV environment. Also, they suggest that horizontal transmission of FeLV is highly efficient under crowded conditions, and that most cats naturally exposed to virus elicit an active immune response.