Contribution of Distal-less to quantitative variation in butterfly eyespots
Contribution of Distal-less to quantitative variation in butterfly eyespots
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DOI：
10.1038/415315a
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发表时间：
2002-01-17
期刊：
影响因子：
64.8
通讯作者：
Long, AD
中科院分区：
文献类型：
--
作者：
Beldade, P;Brakefield, PM;Long, AD
蝴蝶翅膀上的彩色图案为研究进化与发育之间的相互作用提供了理想的材料。它们是视觉上引人注目的选择产品，通常具有明确的适应价值，并且可以进行详细的发育表征（1）。对翅膀模式进化和发育的研究主要集中在热带蝴蝶Bicyclus anynana的眼点上（2）。眼点形态的几个特征存在定量变异（3-5），但导致这种变异的实际基因尚不清楚。另一方面，对翅原基中基因表达模式的研究暗示了眼斑形成的不同发育途径（6-11）。为了将这两组信息联系起来，我们需要确定在所涉及的途径中哪些基因对自然选择可获得的数量变化做出了贡献。在这里，我们开始通过证明候选基因Distal-less（Dll）中的DNA多态性与B中的眼点大小之间的联系来弥合这一差距。anynana。
The colour patterns decorating butterfly wings provide ideal material to study the reciprocal interactions between evolution and development. They are visually compelling products of selection, often with a clear adaptive value, and are amenable to a detailed developmental characterization(1). Research on wing-pattern evolution and development has focused on the eyespots of the tropical butterfly Bicyclus anynana(2). There is quantitative variation for several features of eyespot morphology(3-5) but the actual genes contributing to such variation are unknown. On the other hand, studies of gene expression patterns in wing primordia have implicated different developmental pathways in eyespot formation(6-11). To link these two sets of information we need to identify which genes within the implicated pathways contribute to the quantitative variation accessible to natural selection. Here we begin to bridge this gap by demonstrating linkage between DNA polymorphisms in the candidate gene Distal-less (Dll) and eyespot size in B. anynana.