The aging, demographics, and memory study: Study design and methods
The aging, demographics, and memory study: Study design and methods
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DOI：
10.1159/000087448
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发表时间：
2005-01-01
影响因子：
5.7
通讯作者：
Willis, RJ
中科院分区：
文献类型：
--
作者：
Langa, KM;Plassman, BL;Willis, RJ
目的：我们描述了老龄化，人口统计学和记忆研究（亚当斯）的设计和方法，这是一项新的全国性研究，将提供痴呆和“认知障碍，非痴呆”（CIND）的前因，患病率，结局和成本的数据，使用基于全国代表性健康和退休研究（HRS）的独特研究设计。我们还说明了亚当斯数据的潜在用途，并为感兴趣的研究人员提供有关获取亚当斯和HRS数据的信息。研究方法：亚当斯是美国第一个基于人群的痴呆症研究，包括来自全国所有地区的受试者，同时在基于社区的样本中使用单一的标准化诊断方案。856名年龄在70岁或以上的参与正在进行的HRS的个体的样本接受了广泛的家庭临床和神经心理学评估，以确定正常、CIND或痴呆的诊断。在CIND和痴呆类别中，指定子类别（例如阿尔茨海默病、血管性痴呆）表示认知障碍的病因。结论：将亚当斯痴呆临床评估数据与大量关于健康、卫生保健利用、非正式护理以及经济资源和行为的可用纵向HRS数据相关联，将为研究全国代表性人群样本中CIND和痴呆的发病以及CIND和痴呆的风险因素、患病率、结局和成本提供独特的机会。版权所有（C）2005 S. Karger AG，巴塞尔。
Objective: We describe the design and methods of the Aging, Demographics, and Memory Study (ADAMS), a new national study that will provide data on the antecedents, prevalence, outcomes, and costs of dementia and 'cognitive impairment, not demented' (CIND) using a unique study design based on the nationally representative Health and Retirement Study (HRS). We also illustrate potential uses of the ADAMS data and provide information to interested researchers on obtaining ADAMS and HRS data. Methods: The ADAMS is the first population-based study of dementia in the United States to include subjects from all regions of the country, while at the same time using a single standardized diagnostic protocol in a community- based sample. A sample of 856 individuals age 70 or older who were participants in the ongoing HRS received an extensive in-home clinical and neuropsychological assessment to determine a diagnosis of normal, CIND, or dementia. Within the CIND and dementia categories, subcategories (e.g. Alzheimer's disease, vascular dementia) were assigned to denote the etiology of cognitive impairment. Conclusion: Linking the ADAMS dementia clinical assessment data to the wealth of available longitudinal HRS data on health, health care utilization, informal care, and economic resources and behavior, will provide a unique opportunity to study the onset of CIND and dementia in a nationally representative population- based sample, as well as the risk factors, prevalence, outcomes, and costs of CIND and dementia. Copyright (C) 2005 S. Karger AG, Basel.