The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.
The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.
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DOI：
10.3390/v3060629
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Soldan SS
中科院分区：
文献类型：
--
作者：
Hollidge BS;Weiss SR;Soldan SS
许多因素有利于节肢动物传播病毒（虫媒病毒）的出现和重新出现，包括迁移、气候变化、集约化畜牧生产、国际贸易和运输量的增加以及生态系统的变化（例如，森林砍伐和生物多样性的丧失）。因此，虫媒病毒分布在世界各地，占过去十年中发现的所有新发传染病的30%以上。虽然有些虫媒病毒感染未被发现或与轻微的流感样症状有关，但许多虫媒病毒是重要的人类和兽医病原体，可引起关节炎、胃肠炎、脑炎和出血热等严重疾病，并因牲畜生产力下降和死亡率高而造成毁灭性的经济损失。新兴虫媒病毒的最一致的分子特征之一，除了它们几乎完全使用RNA基因组之外，是包含作为干扰素拮抗剂的病毒非结构蛋白。在这篇综述中，我们描述了这些干扰素拮抗剂和虫媒病毒用于对抗宿主先天免疫反应的常见策略。此外，我们还讨论了与病毒出现和重新出现相关的宿主因素和病毒决定因素之间的复杂相互作用，并确定了疫苗和抗病毒治疗的潜在靶点。
A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequently, arboviruses are distributed worldwide and represent over 30% of all emerging infectious diseases identified in the past decade. Although some arboviral infections go undetected or are associated with mild, flu-like symptoms, many are important human and veterinary pathogens causing serious illnesses such as arthritis, gastroenteritis, encephalitis and hemorrhagic fever and devastating economic loss as a consequence of lost productivity and high mortality rates among livestock. One of the most consistent molecular features of emerging arboviruses, in addition to their near exclusive use of RNA genomes, is the inclusion of viral, non-structural proteins that act as interferon antagonists. In this review, we describe these interferon antagonists and common strategies that arboviruses use to counter the host innate immune response. In addition, we discuss the complex interplay between host factors and viral determinants that are associated with virus emergence and re-emergence, and identify potential targets for vaccine and anti-viral therapies.
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