Treatment of non-traumatic out-of-hospital cardiac arrest with active compression decompression cardiopulmonary resuscitation plus an impedance threshold device.
Treatment of non-traumatic out-of-hospital cardiac arrest with active compression decompression cardiopulmonary resuscitation plus an impedance threshold device.
复制标题
DOI：
10.1016/j.resuscitation.2013.05.002
复制
发表时间：
2013-09
期刊：
影响因子：
6.5
通讯作者：
Aufderheide TP
中科院分区：
文献类型：
--
作者：
Frascone RJ;Wayne MA;Swor RA;Mahoney BD;Domeier RM;Olinger ML;Tupper DE;Setum CM;Burkhart N;Klann L;Salzman JG;Wewerka SS;Yannopoulos D;Lurie KG;O'Neil BJ;Holcomb RG;Aufderheide TP
最近的一项院外心脏骤停（OHCA）临床试验显示，与标准(S) CPR相比，主动加压减压心肺复苏（CPR）加阻抗阈值装置（ACD+ICD）治疗的心源性心脏骤停患者到出院的生存率（HD）和良好的神经功能。目前的分析检查了ACD+ITD治疗是否比标准（S-CPR）治疗所有非创伤性心脏骤停更有效，无论病因如何。这是对一项随机、前瞻性、多中心、意向治疗、OHCA临床试验数据的二次分析。假定患有非创伤性心脏骤停的成年人被纳入研究，并在心脏骤停后随访一年。主要终点是存活至出院时神经功能良好（改良Rankin量表评分≤3分）。2005年10月至2009年7月，共纳入2738例患者（S-CPR = 1335; ACD+ITD =1403）。与S-CPR相比，ACD+ITD对神经功能良好的HD患者的生存率更高：7.9%比5.7% （OR 1.42, 95% CI 1.04, 1.95, p=0.027）。一年生存率也更高：7.9%比5.7% （OR 1.43, 95% CI 1.04, 1.96, p=0.026）。两组中几乎所有的幸存者在一年内都恢复了他们的基线神经功能。两组间主要不良事件发生率相似。与S-CPR相比，对院外非创伤性心脏骤停合并ACD+ITD患者的治疗可显著提高患者出院时的生存率，且神经功能良好。无论心脏骤停的病因如何，经ACD+ITD治疗的患者在心脏骤停后一年生存率显著增加。NCT 00189423 （http://www.clinicaltrials.gov）
A recent out-of-hospital cardiac arrest (OHCA) clinical trial showed improved survival to hospital discharge (HD) with favorable neurologic function for patients with cardiac arrest of cardiac origin treated with active compression decompression cardiopulmonary resuscitation (CPR) plus an impedance threshold device (ACD+ICD) versus standard (S) CPR. The current analysis examined whether treatment with ACD+ITD is more effective than standard (S-CPR) for all cardiac arrests of non-traumatic origin, regardless of the aetiology. This is a secondary analysis of data from a randomized, prospective, multicenter, intention-to-treat, OHCA clinical trial. Adults with presumed non-traumatic cardiac arrest were enrolled and followed for one year post arrest. The primary endpoint was survival to hospital discharge (HD) with favorable neurologic function (modified Rankin Scale score ≤3). Between October 2005 to July 2009, 2738 patients were enrolled (S-CPR = 1335; ACD+ITD =1403). Survival to HD with favorable neurologic function was greater with ACD+ITD compared with S-CPR: 7.9% versus 5.7%, (OR 1.42, 95% CI 1.04, 1.95, p=0.027). One-year survival was also greater: 7.9% versus 5.7%, (OR 1.43, 95% CI 1.04, 1.96, p=0.026). Nearly all survivors in both groups had returned to their baseline neurological function by one year. Major adverse event rates were similar between groups. Treatment of out-of-hospital non-traumatic cardiac arrest patients with ACD+ITD resulted in a significant increase in survival to hospital discharge with favorable neurological function when compared with S-CPR. A significant increase survival rates was observed up to one year after arrest in subjects treated with ACD+ITD, regardless of the etiology of the cardiac arrest. NCT 00189423 (http://www.clinicaltrials.gov)
登录
查看更多内容
影响因子：
8.3
作者：
VANSWIETEN, JC;KOUDSTAAL, PJ;VANGIJN, J
通讯作者：
VANGIJN, J
影响因子：
8.8
作者：
Metzger, Anja K.;Herman, Margot;Yannopoulos, Demetris
通讯作者：
Yannopoulos, Demetris
影响因子：
6.5
作者：
Plaisance, P;Lurie, KG;Payen, D
通讯作者：
Payen, D
影响因子：
6.5
作者：
Yannopoulos, D;McKnite, S;Lurie, KG
通讯作者：
Lurie, KG
影响因子：
37.8
作者：
CUMMINS, RO;CHAMBERLAIN, DA;THIES, WH
通讯作者：
THIES, WH