Are blood group isoantigens lost from malignant prostatic epithelium? Immunohistochemical support for the preservation of the H isoantigen.
Are blood group isoantigens lost from malignant prostatic epithelium? Immunohistochemical support for the preservation of the H isoantigen.
复制标题
恶性前列腺上皮是否会丢失血型同抗原？
DOI：
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发表时间：
1986
影响因子：
8.8
通讯作者：
N. M. Bleehen
中科院分区：
文献类型：
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作者：
P. Vowden;A. D. Lowe;E S Lennox;N. M. Bleehen
以前的研究虽然证明了正常前列腺上皮上存在血型相同的抗原，但未能在恶性前列腺组织上鉴定出这种抗原。用一系列针对A、B、H和Y抗原的血型特异性单抗，对良性前列腺增生症和前列腺癌的血型同种抗原表达进行了再研究。从良性前列腺增生区获得的结果与发表的结果大体一致，尽管我们无法检测到A或B血型同种抗原，但在12个肿瘤中有10个发现了2H和Y型同种抗原。这些发现虽然与以前报道的结果不同，但支持了个体发生、肿瘤发生和血型同种抗原表达之间的联系，也支持了2型结构与恶性转化之间的联系。
Previous studies while demonstrating the presence of blood group isoantigens on normal prostatic epithelium have failed to identify such antigens on malignant prostatic tissue. Using a series of blood group specific monoclonal antibodies directed towards the A, B, H and Y antigens we have reinvestigated blood group isoantigen expression in both benign prostatic hypertrophy and prostatic adenocarcinoma. Results obtained from areas of benign prostatic hypertrophy are in broad agreement with those published however though we were unable to detect either A or B blood group isoantigens Type 2H and Y isoantigens were identified in 10 of the 12 tumours. These findings, while differing from previously reported results, lend support to the suggested connection between ontogenesis, oncogenesis and blood group isoantigen expression and also support the proposed link between Type 2 structures and malignant transformation.
针对人类癌细胞系的小鼠单克隆抗体，对血型和相关抗原具有特异性。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hansson,GC;Karlsson,KA;Larson,G;McKibbin,JM;Blaszczyk,M;Herlyn,M;Steplewski,Z;Koprowski,H
通讯作者：
Koprowski,H