Absorptive hyperoxaluria leads to an increased risk for urolithiasis or nephrocalcinosis in cystic fibrosis
Absorptive hyperoxaluria leads to an increased risk for urolithiasis or nephrocalcinosis in cystic fibrosis
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DOI：
10.1053/j.ajkd.2005.06.003
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发表时间：
2005-09-01
影响因子：
13.2
通讯作者：
Hesse, A
中科院分区：
文献类型：
--
作者：
Hoppe, B;von Unruh, GE;Hesse, A
背景资料。高草酸尿已被认为是囊性纤维化患者尿石症或肾钙症发生率增加的原因。高草酸尿症可能是由于脂肪吸收不良和缺乏草酸分解菌等肠道草酸降解细菌所致。为了更好地阐明其病理生理学特征，我们前瞻性地研究了CF患者，方法是测定这些参数并每年进行两次肾脏超声检查。方法：对37例5~37岁(女性15例，男性22例)持续高草酸尿症患者，除常规尿液检查外，还检测粪便中0种产甲酸菌，测定血浆草酸，并进行草酸吸收试验。结果高草酸尿症(草酸，46~141 mg/1.73m(2)/24 h[0.51~1.57 mm ol/1.73 m(2)/24 h]；正常，3.3 mg/1.73 m(2)/24 h[草酸1.9 mm ol/1.73 m(2)/24 h])。17例患者尿草酸钙饱和度升高(5.62至28.9相对单位；正常女性，
Background. Hyperoxaluria has been incriminated to account for the increased incidence of urolithiasis or nephrocalcinosis in patients with cystic fibrosis (CF). Hyperoxaluria presumably is caused by fat malabsorption and the absence of such intestinal oxalate-degrading bacteria as Oxalobacter formigenes. To better elucidate its pathophysiological characteristics, we prospectively studied patients with CF by determining these parameters and performing renal ultrasonography twice yearly. Methods: In addition to routine tests in urine (lithogenic and stone-inhibitory substances), the presence of 0 formigenes was tested in stool, plasma oxalate was measured, and a [C-13(2)]oxalate absorption test was performed in 37 patients with CF aged 5 to 37 years (15 females, 22 males) who were constantly hyperoxaluric before the study. Results Hyperoxaluria (oxalate, 46 to 141 mg/1.73 m(2)/24 h [0.51 to 1.57 mmol/1.73 m(2)/24 h]; normal, 3.3 mg/1.73 m(2)/24 h [>1.9 mmol/1.73 m(2)/24 h]). Urine calcium oxalate saturation was elevated in 17 patients (5.62 to 28.9 relative units; normal female,