Radiotherapy for stage I or II hypopharyngeal carcinoma.
Radiotherapy for stage I or II hypopharyngeal carcinoma.
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DOI：
10.1093/jrr/rrs044
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发表时间：
2012-11-01
影响因子：
2
通讯作者：
Nibu K
中科院分区：
文献类型：
--
作者：
Nishimura H;Sasaki R;Yoshida K;Miyawaki D;Okamoto Y;Kiyota N;Saito M;Otsuki N;Nibu K
下咽鳞状细胞癌（HPSCC）通常在晚期被诊断，早期HPSCC相对罕见。由于早期HPSCC的罕见性，很少有关于放射治疗（RT）在其治疗中的疗效的报道。我们回顾性分析了1991年5月至2010年6月期间45例I期和II期HPSCC患者的临床记录。患者特征如下：中位年龄66岁（范围44-90岁）;男性/女性，39/6; T1/T2，27/18。照射剂量范围为60 ~ 72戈伊（中位数：70戈伊）。45例患者中，21例接受了同期化疗。中位随访时间为62个月，5年总生存率为81%。局部失败5例，5年局部控制率83%。所有局部复发均经手术成功挽救。5年喉功能保留率为92%。急性毒性是可控的。3级喉水肿和3级甲状腺功能减退各1例。未观察到其他3级或以上晚期不良事件。基于这些结果，RT似乎是早期HPSCC的有效治疗方式，具有良好的器官保护和可接受的不良事件。早期发现和准确处理局部复发和第二恶性肿瘤被认为是至关重要的。
Hypopharyngeal squamous cell carcinoma (HPSCC) is usually diagnosed at an advanced stage, and early-stage HPSCC is relatively rare. Because of the rarity of early-stage HPSCC, few reports have been published on the efficacy of radiotherapy (RT) in its treatment. We retrospectively reviewed the clinical records of 45 consecutive patients with Stage I and II HPSCC from May 1991 to June 2010. Patient characteristics were as follows: median age, 66 years (range, 44–90 years); male/female, 39/6; and T1/T2, 27/18. The irradiation dose ranged from 60 to 72 Gy (median: 70 Gy). Of the 45 patients, 21 underwent concurrent chemotherapy. With a median follow-up period of 62 months, the 5-year overall survival rate was 81%. Local failure occurred in 5 patients, and the 5-year local control rate was 83%. All local recurrences were successfully salvaged by surgery. The 5-year functional larynx preservation rate was 92%. Acute toxicity was manageable. Grade 3 laryngeal edema and Grade 3 hypothyroidism occurred in 1 patient each. No other late adverse events of Grade 3 or greater were observed. Based on these results, RT seemed to be an effective treatment modality for early HPSCC, with favorable organ preservation and acceptable adverse events. Early detection and accurate management of local recurrence and second malignancy was deemed to be critical.
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DOI：
10.1002/hed.1044
发表时间：
2001-05-01
影响因子：
2.9
作者：
Amdur, RJ;Mendenhall, WM;Cassisi, NJ
通讯作者：
Cassisi, NJ
影响因子：
158.5
作者：
Forastiere, AA;Goepfert, H;Cooper, J
通讯作者：
Cooper, J
DOI：
10.1016/0360-3016(93)90518-z
发表时间：
1993-12-01
影响因子：
7
作者：
MENDENHALL, WM;PARSONS, JT;MILLION, RR
通讯作者：
MILLION, RR
DOI：
10.1002/hed.20051
发表时间：
2004-08-01
影响因子：
2.9
作者：
Makeieff, M;Mercante, G;Guerrier, B
通讯作者：
Guerrier, B
影响因子：
51.1
作者：
Nutting, Christopher M.;Morden, James P.;Harrington, Kevin J.;Urbano, Teresa Guerrero;Bhide, Shreerang A.;Clark, Catharine;Miles, Elizabeth A.;Miah, Aisha B.;Newbold, Kate;Tanay, MaryAnne;Adab, Fawzi;Jefferies, Sarah J.;Scrase, Christopher;Yap, Beng K.;A'Hern, Roger P.;Sydenham, Mark A.;Emson, Marie;Hall, Emma
通讯作者：
Hall, Emma