Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis.
Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis.
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DOI：
10.1186/ar2642
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发表时间：
2009
影响因子：
4.9
通讯作者：
de Vlam K
中科院分区：
文献类型：
--
作者：
Lories RJ;Luyten FP;de Vlam K
中和肿瘤坏死因子的靶向治疗通常能够控制脊柱关节炎的体征和症状。然而，最近的动物模型数据和临床观察表明，控制炎症可能不足以阻止这些患者的疾病进展为关节强直。骨形态发生蛋白和WNTs（wingless-type like）可能在强直中起重要作用，并可能成为治疗的靶点。炎症和新骨形成之间的关系尚不清楚。本文综述了我们对关节强直认识的进展，并对炎症和关节强直之间的关系提出了另一种观点。
Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However, recent animal model data and clinical observations indicate that control of inflammation may not be sufficient to impede disease progression toward ankylosis in these patients. Bone morphogenetic proteins and WNTs (wingless-type like) are likely to play an important role in ankylosis and could be therapeutic targets. The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis.