The imbalance of Th17 and regulatory T cells in pemphigus patients
The imbalance of Th17 and regulatory T cells in pemphigus patients
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天疱疮患者Th17和调节性T细胞的失衡
DOI：
10.1684/ejd.2013.2177
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发表时间：
2013-11-01
影响因子：
2.5
通讯作者：
Pan, Meng
中科院分区：
文献类型：
--
作者：
Xu, Ren-Chao;Zhu, Hai-Qin;Pan, Meng
天疱疮是一种复杂的皮肤自身免疫性大疱性疾病，其发病机制尚不完全清楚。抗桥粒芯糖蛋白1（Dsg 1）和抗Dsg 3自身抗体在天疱疮的发病机制中起重要作用。目的：目的探讨辅助性T细胞17（Th 17）和调节性T细胞（Treg）在天疱疮发病机制中的作用。研究方法：通过FACS测定两组中表达CD 3（+）CD 8（-）IL-17的Th细胞和CD 4（+）CD 25（hi）Foxp 3（+）Treg细胞的水平，沿着抗Dsg 1和Dsg 3抗体滴度。对Th 17和Treg细胞之间的相关性进行分析。结果如下：天疱疮患者Th 17细胞数量显著高于正常对照组（P = 0.014），尤其是在急性发作期和慢性活动期（P = 0.004和0.022）。相反，天疱疮患者Treg细胞明显少于对照组（P
Pemphigus is a complex dermatologic autoimmune bullous disease whose pathogenic mechanism is not fully understood. Anti-desmoglein-1 (Dsg1) and anti- Dsg3 autoantibodies play an important role in the pathogenesis of pemphigus. Objectives: To investigate the role of T-helper17 (Th17) and regulatory T (Treg) cells in the pathogenesis of pemphigus in fifty-one patients and twenty-six healthy individuals (control group). Methods: Levels of CD3(+)CD8(-) IL-17 expressing Th cells and CD4(+)CD25(hi)Foxp3(+) Treg cells were determined by FACS in both groups, along with anti-Dsg1 and Dsg3 antibody titers. An analysis of the correlation between Th17 and Treg cells was performed. Results: Th17 cell numbers were significantly higher in pemphigus patients than in normal controls (P = 0.014), especially in the acute onset and chronic active stages (P = 0.004 and 0.022). Conversely, Treg cells in pemphigus patients were significantly fewer than in the control group (P