Normative database of retinal nerve fiber layer and macular retinal thickness in a Thai population
Normative database of retinal nerve fiber layer and macular retinal thickness in a Thai population
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DOI：
10.1007/s10384-008-0538-6
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发表时间：
2008-11-01
影响因子：
2.4
通讯作者：
Wattananikorn, Sopa
中科院分区：
文献类型：
--
作者：
Manassakorn, Anita;Chaidaroon, Winai;Wattananikorn, Sopa
为研究泰国人群视网膜神经纤维层（RNFL）的分布和光学相干断层扫描（OCT）测量的黄斑视网膜厚度，我们研究了250名健康受试者[年龄18岁，球镜屈光不正在+/-6屈光度（D）以内，散光为3D，无眼部病变]的每只眼。进行完整的眼部检查、标准自动视野检查、OCT快速RNFL和黄斑厚度测量，并拍摄光盘照片。分析两种厚度的分布，包括它们与人口统计学数据的关系，研究人群的平均+/- SD年龄为44.7 +/- 12.2岁。平均+/- SD RNFL厚度为109.3 +/- 10.5 m，比OCT标准数据库中的厚度厚10%。RNFL每10年下降2.3m（P < 0.001）。性别和球镜当量与RNFL变薄无关。平均+/- SD中央凹厚度为183.2 +/- 1.3 m。外区黄斑厚度明显薄于内区（P < 0.001）。四个象限中颞区最薄（P < 0.001）。除黄斑中心外，所有黄斑区的变薄均与年龄增长有关（P < 0.05），泰国人群的RNFL厚度比原始标准数据库厚约10%。黄斑厚度和视网膜神经纤维层厚度在上级和下象限随着年龄的增长而减少。
To investigate the distribution of retinal nerve fiber layer (RNFL) and macular retinal thickness measured by optical coherence tomography (OCT) in a Thai population.We studied one eye each of 250 healthy subjects [age a parts per thousand yen 18 years; spherical refractive error within +/- 6 diopters (D); astigmatism a parts per thousand currency sign3 D; no ocular pathology]. A complete eye examination, standard automated perimetry, and fast RNFL and macular thickness measurement by OCT were performed, and a disc photograph was taken. The distributions of both thicknesses, including their relationship with demographic data, were analyzed.The mean +/- SD age of the study population was 44.7 +/- 12.2 years. The mean +/- SD RNFL thickness was 109.3 +/- 10.5 m, which was 10% thicker than that in the OCT normative database. RNFL decreased 2.3 m per decade (P < 0.001). Sex and spherical equivalent were not associated with RNFL thinning. The mean +/- SD central foveal thickness was 183.2 +/- 1.3 m. The macular thickness in the outer area was significantly thinner than that in the inner area (P < 0.001). The temporal regions were the thinnest among the four quadrants (P < 0.001). Thinning of all macular areas, except the center, was found to be associated with advancing age (P < 0.05).RNFL thickness in the measured Thai population was about 10% thicker than that in the original normative database. Macular thickness and RNFL thickness in the superior and inferior quadrants decreased with advancing age.