A population-based prospective cohort study of personal exposure to magnetic fields during pregnancy and the risk of miscarriage
A population-based prospective cohort study of personal exposure to magnetic fields during pregnancy and the risk of miscarriage
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DOI：
10.1097/00001648-200201000-00004
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发表时间：
2002-01-01
期刊：
影响因子：
5.4
通讯作者：
Iriye, R
中科院分区：
文献类型：
--
作者：
Li, DK;Odouli, R;Iriye, R
为了研究磁场对流产风险的影响，我们在一家大型健康维护组织的孕妇中进行了一项基于人群的前瞻性队列研究。所有妊娠期小于10周且居住在旧金山弗朗西斯科地区的妊娠试验阳性的女性都被联系参与本研究。我们进行了面对面的访谈，以获得有关流产风险因素和其他潜在混杂因素的信息。所有参与者还被要求佩戴磁场测量仪24小时，并记录他们的活动日记。通过搜索健康维护组织的数据库、查阅病历和电话随访，获得所有参与者的妊娠结局。我们使用考克斯比例风险模型来检查磁场流产的关联。最终分析共纳入969例受试者。虽然我们没有观察到流产风险与平均磁场水平之间的关联，但流产风险随着最大磁场暴露水平的增加而增加，阈值约为16毫高斯（mG）。与磁场暴露大于或等于16 mG（vs < 16 mG）相关的率比（RR）为1.8 [95%置信区间（CI）= 1.2-2.7]。最大磁场暴露水平（三分位数）为16 mG时，风险仍然升高。早期流产（< 10孕周）（RR = 2.2，95%CI = 1.2-4.0）和多胎流产或生育力低下的“易感”妇女（RR = 3.1，95%CI = 1.3-7.7）的相关性更强。在排除那些在测量期间表示其日常活动模式不代表其典型的怀孕期间日常活动的妇女后，这种关联得到了加强; RR = 2.9（95% CI = 1.6-5.3）最大磁场暴露大于或等于16 mG，RR = 5.7早期流产的RR = 4.0（95% CI = 1.4-11.5）。我们的研究结果提供了强有力的前瞻性证据，产前最大磁场暴露超过一定水平（可能约16 mG）可能与流产风险。这种观察到的相关性不太可能是由于不受控制的偏倚或不可测量的混杂因素。
To study the effect of magnetic fields on the risk of miscarriage, we conducted a population-based prospective cohort study among pregnant women within a large health maintenance organization. All women with a positive pregnancy test at less than 10 weeks of gestation and residing in the San Francisco area were contacted for participation in the study. We conducted in-person interviews to obtain information on risk factors for miscarriage and other potential confounders. All participants were also asked to wear a magnetic field, measuring meter for 24 hours and to keep a diary of their activities. Pregnancy outcomes were obtained for all participants by searching the health maintenance organization's databases, reviewing medical charts, and telephone follow,up. We used the Cox proportional hazard model for examining the magnetic field-miscarriage association. A total of 969 subjects were included in the final analyses. Although we did not observe an association between miscarriage risk and the average magnetic field level, miscarriage risk increased with an increasing level of maximum magnetic field exposure with a threshold around 16 milligauss (mG). The rate ratio (RR) associated with magnetic field exposure greater than or equal to 16 mG (vs < 16 mG) was 1.8 [95% confidence interval (CI) = 1.2-2.7]. The risk remained elevated for levels (in tertiles) of maximum magnetic field exposure 16 mG. The association was stronger for early miscarriages (< 10 weeks of gestation) (RR = 2.2, 95% Cl = 1.2-4.0) and among "susceptible" women with multiple prior fetal losses or subfertility (RR = 3.1, 95% CI = 1.3-7.7). After excluding women who indicated that their daily activity pattern during the measurements did not represent their typical daily activity during pregnancy, the association was strengthened; RR = 2.9 (95% CI = 1.6-5.3) for maximum magnetic field exposure greater than or equal to 16 mG, RR = 5.7 (95% CI = 2.1-15.7) for early miscarriage, and RR = 4.0 (95% CI = 1.4-11.5) among the susceptible women. Our findings provide strong prospective evidence that prenatal maximum magnetic field exposure above a certain level (possibly around 16 mG) may be associated with miscarriage risk. This observed association is unlikely to be due to uncontrolled biases or unmeasured confounders.