HDL particle number and size as predictors of cardiovascular disease.
HDL particle number and size as predictors of cardiovascular disease.
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DOI：
10.3389/fphar.2015.00218
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发表时间：
2015
影响因子：
5.6
通讯作者：
Kontush A
中科院分区：
文献类型：
--
作者：
Kontush A
先前的研究表明，作为心血管疾病的预测因子，循环高密度脂蛋白（HDL）颗粒浓度降低可能优于HDL-胆固醇（HDL-C）水平上级。因此，HDL颗粒数的测量具有改善心血管风险评估的潜力。此外，这种测量可以与靶向HDL的新治疗方法的评价相关。对HDL颗粒谱的现代深入分析可能会进一步改善心血管风险的评估。尽管HDL亚群的循环浓度与心血管疾病的临床相关性仍存在争议，但大HDL颗粒数量与心血管疾病之间的负相关性表明HDL颗粒谱的评估在临床上是有用的。在大规模临床研究中，平均HDL大小降低与心血管疾病同样相关。由于HDL-C主要由大的富含脂质的HDL颗粒在循环中携带，HDL大小和心血管风险之间的反比关系可能继发于HDL颗粒、HDL-C和大HDL的血浆水平。因此，流行病学数据表明，与HDL-C相比，HDL颗粒数可能代表更相关的治疗靶点。
Previous studies indicate that reduced concentrations of circulating high-density lipoprotein (HDL) particles can be superior to HDL-cholesterol (HDL-C) levels as a predictor of cardiovascular disease. Measurements of HDL particle numbers, therefore, bear a potential for the improved assessment of cardiovascular risk. Furthermore, such measurement can be relevant for the evaluation of novel therapeutic approaches targeting HDL. Modern in-depth analyses of HDL particle profile may further improve evaluation of cardiovascular risk. Although clinical relevance of circulating concentrations of HDL subpopulations to cardiovascular disease remains controversial, the negative relationship between the number of large HDL particles and cardiovascular disease suggests that assessment of HDL particle profile can be clinically useful. Reduced mean HDL size is equally associated with cardiovascular disease in large-scale clinical studies. Since HDL-C is primarily carried in the circulation by large, lipid-rich HDL particles, the inverse relationship between HDL size and cardiovascular risk can be secondary to those established for plasma levels of HDL particles, HDL-C, and large HDL. The epidemiological data thereby suggest that HDL particle number may represent a more relevant therapeutic target as compared to HDL-C.