MULTIPLE G-PROTEIN-COUPLED PATHWAYS INHIBIT N-TYPE CA CHANNELS OF NEURONS
MULTIPLE G-PROTEIN-COUPLED PATHWAYS INHIBIT N-TYPE CA CHANNELS OF NEURONS
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DOI：
10.1016/0024-3205(95)00038-8
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发表时间：
1995-02-10
期刊：
影响因子：
6.1
通讯作者：
WOLLMUTH, LP
中科院分区：
文献类型：
--
作者：
HILLE, B;BEECH, DJ;WOLLMUTH, LP
毒蕈碱受体通过两条信号通路抑制颈上神经节神经元中的 Ca2+ 电流。一种对百日咳毒素敏感，并通过通道上的膜分隔途径快速发挥作用。另一种对百日咳毒素不敏感，通过未知的第二信使发挥作用较慢。这些途径与其他几种激动剂共享。
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.