Barriers and more: functions of tight junction proteins in the skin
Barriers and more: functions of tight junction proteins in the skin
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DOI：
10.1111/j.1749-6632.2012.06554.x
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Brandner, Johanna M.
中科院分区：
文献类型：
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作者：
Kirschner, Nina;Brandner, Johanna M.
尽管紧密连接 (TJ) 结构（或次级表皮屏障）的存在被假设了很长一段时间，但表皮中 TJ 蛋白（occludin、ZO-1 和 ZO-2）的首次描述直到最近才出现。从那时起，人们收集了大量关于 TJ 和 TJ 蛋白的新见解，包括它们在皮肤中的功能作用。特别有趣的是，表皮作为多层上皮，表现出非常复杂的 TJ 蛋白定位模式，这导致不同层中 TJ 蛋白复合物的不同组成。在这篇综述中，我们总结了目前关于表皮中 TJ 蛋白在屏障功能、细胞极性、囊泡运输、分化和增殖中的作用的知识。我们假设 TJ 蛋白实现 TJ 结构依赖和结构无关的功能，并且 TJ 蛋白的特定功能可能取决于其表达的表皮层。
Although the existence of tight junction (TJ) structures (or a secondary epidermal barrier) was postulated for a long time, the first description of TJ proteins in the epidermis (occludin, ZO-1, and ZO-2) was only fairly recent. Since then, a wealth of new insights concerning TJs and TJ proteins, including their functional role in the skin, have been gathered. Of special interest is that the epidermis as a multilayered epithelium exhibits a very complex localization pattern of TJ proteins, which results in different compositions of TJ protein complexes in different layers. In this review, we summarize our current knowledge about the role of TJ proteins in the epidermis in barrier function, cell polarity, vesicle trafficking, differentiation, and proliferation. We hypothesize that TJ proteins fulfill TJ structure-dependent and structure-independent functions and that the specific function of a TJ protein may depend on the epidermal layer where it is expressed.