Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT
Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT
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DOI：
10.1016/s0955-2863(03)00101-3
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发表时间：
2003-09-01
影响因子：
5.6
通讯作者：
Wander, RC
中科院分区：
文献类型：
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作者：
Ciubotaru, I;Lee, YS;Wander, RC
背景：动脉粥样硬化的发生是一个复杂的过程，包括低度炎症和脂质代谢紊乱。虽然饮食中的鱼和鱼油改善了这两个危险因素中的后者，但它们对前者的影响尚不清楚。目的：本研究探讨了补充鱼油对血清C反应蛋白（CRP）、白细胞介素-6（IL-6）和血脂的影响。方法和结果：将30名健康受试者随机分为3组，分别补充14 g/d的红花油（SO）、7 g/d的红花油和鱼油（LFO），或14克/天鱼油（HFO）。测量包括血清高敏C反应蛋白，血浆中的IL-6和从24小时脂多糖（LPS）刺激的全血中收集的细胞培养上清液中的IL-6，以及血脂标志物。根据体重指数（BMI）调整了CRP和IL-6。与SO相比，鱼油补充剂显著降低了CRP和IL-6，LFO组的效果大于HFO组。血浆三酰甘油（TG）和TG/HDL-C比值显着降低在HFO相比SO group.Conclusions：这些结果表明，膳食鱼油可能会降低心血管疾病的风险，通过调制血脂和炎症标志物在健康的绝经后妇女。(C)2003年爱思唯尔公司All rights reserved.
Background: Atherogenesis is a complex process involving both a low-grade inflammation and a disturbed lipid profile. Although dietary fish and fish oil improve the latter of these two risk factors, their impact on the former is less clear.Objective: This study addressed the effect of supplementation with fish oil in doses achievable with diet on serum C-reactive protein (CRP), interleukin-6 (IL-6), and the lipid profile.Methods and results: Thirty healthy subjects taking HRT were randomly divided into three groups and supplemented for five weeks with 14g/day safflower oil (SO), 7g/day of both safflower oil and fish oil (LFO), or 14g/day fish oil (HFO). Measurements included serum high-sensitivity CRP, IL-6 in plasma and in cell culture supernatant collected from 24-hr lipopolysaccharide (LPS)-stimulated whole blood, and lipid profile markers. CRP and IL-6 were adjusted for body mass index (BMI). Fish oil supplementation significantly decreased CRP and IL-6 compared to SO, with a greater effect in the LFO than HFO groups. Plasma triacylglycerol (TG) and the TG/HDL-C ratio were significantly lower in the HFO compared to the SO group.Conclusions: These results suggest that dietary fish oil may decrease the risk for cardiovascular disease through the modulation of both plasma lipids and inflammatory markers in healthy postmenopausal women. (C) 2003 Elsevier Inc. All rights reserved.