High opiate receptor binding potential in the human lateral pain system
High opiate receptor binding potential in the human lateral pain system
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DOI：
10.1016/j.neuroimage.2005.10.033
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发表时间：
2006-04-15
期刊：
影响因子：
5.7
通讯作者：
Schreckenberger, M
中科院分区：
文献类型：
--
作者：
Baumgärtner, U;Buchholz, HG;Schreckenberger, M
为了确定阿片受体分布如何与人脑中的伤害性区域分布共定位，11名男性健康志愿者在静息条件下用亚型非选择性阿片样物质放射性配体[F-18]氟乙基-二丙诺啡进行了一次PET扫描。结合电位（BP），一个参数的区域大脑阿片受体的可用性，计算使用枕叶皮质作为参考区域。在单个MR图像上定义以下感兴趣区域（ROI）：丘脑、传感器、运动带（SI/MI区）、额盖、顶叶盖、前岛叶皮质、后岛叶皮质、前扣带皮质（行政协调会;仅“经典ACC”的膝下和膝下部分），中扣带皮质[F-18]氟乙基-二丙诺啡的BP在感觉运动条中最低（0.30）。血压最高的部位为丘脑（1.36）、基底节（壳核1.22，尾核1.16）和杏仁核（1.21）。扣带皮层ACC组血压（1.11）高于MCC组（0.86）。在岛盖区，我们发现所有ROI的BP均较高：前岛盖（1.16）、后岛盖（1.05）、额岛盖（0.99）和顶叶岛盖（0.77）。阿片受体BP的个体间变异性的因子分析显示有4个因子（95%解释方差）：（1）岛盖区、ACC、MCC和壳核，（2）杏仁核和丘脑，（3）尾状核和丘脑，（4）SUMI和MCC。（额顶叶盖和额顶叶盖）具有显著高于SI/Ml的阿片受体BP，与内侧疼痛系统的前部和小扣带区域相当。这些研究结果表明，阿片类药物的皮质抗伤害性感受作用不仅是由ACC和MCC介导的，但也由盖岛皮质，如果它可以假设，阿片类药物结合介导的抗伤害性感受在这些结构。(c)2005年爱思唯尔公司All rights reserved.
To determine how opiate receptor distribution is co-localized with the distribution of nociceptive areas in the human brain, eleven male health), volunteers underwent one PET scan with the subtype-nonselective opioidergic radioligand [F-18]fluoroethyl-diprenorphine under resting conditions. The binding potential (BP), a parameter for the regional cerebral opioid receptor availability, was computed using the occipital cortex as reference region. The following regions of interest (ROIs) were defined on individual MR images: thalamus, sensor), motor strip (SI/MI area), frontal operculum, parietal operculum, anterior insular cortex, posterior insular cortex, anterior cingulate cortex (ACC; peri- and subgenual part of "classical ACC" only), midcingulate cortex (MCC, posterior part of "classical ACC"), putamen, caudate nucleus and the amygdala.BP for [F-18]fluoroethyl-diprenorphine was lowest in the sensory motor strip (0.30). Highest BP was found in thalamus (1.36), basal ganglia (putamen 1.22, caudate 1.16) and amygdala (1.21). In the cingulate cortex, ACC (1.11) had higher BP than MCC (0.86). In the operculo-insular region, we found high BPs in all ROIs: anterior insula (1.16), posterior insula (1.05), frontal operculum (0.99) and parietal operculum (0.77). Factor analysis of interindividual variabilitv of opiate receptor BP revealed four factors (95% explained variance): (1) operculo-insular areas, ACC, MCC and putamen, (2) amygdala and thalamus, (3) caudate and thalamus, (4) SUMI and MCC.Nociceptive areas of the lateral pain system (frontoparietal operculum and insula) have opiate receptor BPs significantly higher than SI/Ml, comparable to anterior and miticingulate areas of the medial pain system. These findings suggest that the cortical antinociceptive effects of opiates are not only mediated by ACC and MCC, but also by the operculo-insular cortex, if it can be assumed that opioid binding mediates anti-nociception in those structures. (c) 2005 Elsevier Inc. All rights reserved.