Molecular characterization of a virulent canine coronavirus BGF strain
Molecular characterization of a virulent canine coronavirus BGF strain
复制标题
DOI：
10.1016/j.virusres.2004.02.038
复制
发表时间：
2004-08-01
期刊：
影响因子：
5
通讯作者：
Morris, TH
中科院分区：
文献类型：
--
作者：
Sanchez-Morgado, JM;Poynter, S;Morris, TH
与小狗腹泻爆发相关的犬冠状病毒 (CCoV) 分离株 (BGF) 的分子特征显示，其与 Insavc-1 减毒株有 92.7% 的同一性。犬冠状病毒 BGF 揭示了一种全长非结构蛋白 3b (nsp 3b)，与其他冠状病毒的毒力相关。膜蛋白氨基末端结构域的高度分歧区域可能与避免宿主免疫反应有关。这种新的犬冠状病毒株可以帮助识别冠状病毒的毒力因子。 (C) 2004 Elsevier B.V. 保留所有权利。
Molecular characterisation of a canine coronavirus (CCoV) isolate (BGF), associated with an outbreak of diarrhoea in puppies, showed 92.7% identity with attenuated Insavc-1 strain. Canine coronavirus BGF revealed a full length non-structural protein 3b (nsp 3b), associated with virulence in other coronaviruses. and a highly divergent region at the amino terminal domain of the membrane protein that may be implicated in avoiding the host immune reaction. This new canine coronavirus strain could help to identify virulence factors in coronavirus. (C) 2004 Elsevier B.V. All rights reserved.