EFFECTS OF NICOTINE ON FINGER TAPPING RATE IN NONSMOKERS
EFFECTS OF NICOTINE ON FINGER TAPPING RATE IN NONSMOKERS
复制标题
DOI：
10.1016/0091-3057(86)90377-1
复制
发表时间：
1986-10-01
影响因子：
3.6
通讯作者：
JARVIS, MJ
中科院分区：
文献类型：
--
作者：
WEST, RJ;JARVIS, MJ
进行了五个实验，研究尼古丁对非吸烟者手指敲击率的影响。在每一个实验中，受试者用一根手指尽可能快地敲击传统的计算机键盘。在第一个实验中，两个2毫克剂量的鼻尼古丁溶液（NNS），但不是由一个非活性的解决方案，提高了敲击率。第二项研究是双盲进行的，结果表明，单次2 mg剂量的NNS可使敲击性能提高约5%，而极低剂量（0.15 mg）的NNS和安慰剂则没有效果。NNS的效果是从每次试验开始就带来持续的割胶率增加。第三项研究发现，尼古丁对敲击的影响被单剂量2.5毫克的中枢胆碱能阻断剂美加明降低，但安慰剂没有。实验四在服用两剂2 mg NNS后跟踪一小时的敲击速度，结果表明，在受试者体内，这种行为测量可以对尼古丁效应的时间过程提供非常一致且灵敏的生物测定。最后的实验发现，每小时重复给药一次2 mg NNS，持续6小时，每次给药后，敲击速度可靠地增加，没有急性耐受性的证据。结果表明，尼古丁可以大大提高非吸烟者在简单运动任务中的表现，可能是通过其对胆碱能通路的作用。NNS首次提供了一种有效的方法来检查尼古丁对非吸烟者的影响。
Five experiments were conducted investigating the effects of nicotine on finger tapping rate in non-smokers. In each experiment subjects tapped as fast as possible a fixed number of times with one finger on a conventional computer keyboard. In the first experiment tapping rate was increased by two 2 mg dosed of an nasal nicotine solution (NNS) but not by an inactive solution. The second study was carried out double-blind and showed that a single 2 mg dose of NNS improved tapping performance by about 5% whereas a very low dose (0.15 mg) NNS and a placebo had no effect. The effect of the NNS was to bring about a sustained increase in tapping rate from the start of each trial. The third study found that the effect of nicotine on tapping was reduced by a single 2.5 mg dose of the central cholinergic blocking agent, mecamylamine, but not by a placebo. Experiment four followed tapping rate for one hour after a dose of two 2 mg NNS and showed that within a subject this behavioural measure can provide a very consistent and sensitive bio-assay of the time course of nicotine effects. The final experiment found that repeated dosing with one 2 mg NNS on an hourly schedule for six hours produced a reliable increase in tapping speed after each dose with no evidence of acute tolerance. The results indicate that nicotine can substantially improve performance by non-smokers on a simple motor task, probably via its action on cholinergic pathways. NNS provides for the first time an effective means of examining the effects of nicotine on non-smokers.