Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone
Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone
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DOI：
10.1016/j.freeradbiomed.2004.04.021
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发表时间：
2004-07-15
影响因子：
7.4
通讯作者：
Johnson, TE
中科院分区：
文献类型：
--
作者：
De Castro, E;De Castro, SH;Johnson, TE
活性氧类物质攻击所造成的分子损伤的累积是衰老的原因之一。因此，一些对活性氧类物质表现出更强抗性的突变生物应该寿命更长。我们发现，对胡桃醌（一种产生活性氧类物质的化合物）有抗性的秀丽隐杆线虫突变体进行筛选，能够鉴定出长寿突变体。实际上，所分离出的六个抗性突变体中有四个也是长寿的。这项研究再次阐明了氧化应激与衰老过程之间的紧密关系。（C）2004爱思唯尔公司。保留所有权利。
The accumulation of molecular damage from attack by reactive oxygen species is one cause of aging. Therefore, some mutant organisms showing increased resistance to reactive oxygen species should live longer. We show that selection for Caenorhabditis elegans mutants that are resistant to juglone, a reactive oxygen species-generating compound, leads to the identification of long-lived mutants. Indeed, four of six resistant mutants isolated were also long-lived. This study illustrates once more the strong relationship between oxidative stress and the aging processes. (C) 2004 Elsevier Inc. All rights reserved.